Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3680314..3680932 Replicon chromosome
Accession NZ_LR890198
Organism Escherichia coli isolate MINF_1D-sc-2280456

Toxin (Protein)


Gene name Hha Uniprot ID H5UYE2
Locus tag JMV89_RS17575 Protein ID WP_001291435.1
Coordinates 3680714..3680932 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID S1PTH5
Locus tag JMV89_RS17570 Protein ID WP_000344800.1
Coordinates 3680314..3680688 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JMV89_RS17560 3675404..3676597 + 1194 WP_001295833.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
JMV89_RS17565 3676620..3679769 + 3150 WP_001132480.1 multidrug efflux RND transporter permease subunit -
JMV89_RS17570 3680314..3680688 + 375 WP_000344800.1 Hha toxicity modulator TomB Antitoxin
JMV89_RS17575 3680714..3680932 + 219 WP_001291435.1 hemolysin expression modulator Hha Toxin
JMV89_RS17580 3681106..3681657 + 552 WP_000102539.1 maltose O-acetyltransferase -
JMV89_RS17585 3681773..3682243 + 471 WP_000136192.1 YlaC family protein -
JMV89_RS17590 3682407..3683957 + 1551 WP_001298569.1 cyclic-guanylate-specific phosphodiesterase PdeB -
JMV89_RS17595 3683999..3684352 - 354 WP_000878140.1 DUF1428 domain-containing protein -
JMV89_RS17605 3684731..3685042 + 312 WP_000409908.1 MGMT family protein -
JMV89_RS17610 3685073..3685645 - 573 WP_000779831.1 YbaY family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-117)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T290255 WP_001291435.1 NZ_LR890198:3680714-3680932 [Escherichia coli]
MSEKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14557.39 Da        Isoelectric Point: 4.7395

>AT290255 WP_000344800.1 NZ_LR890198:3680314-3680688 [Escherichia coli]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINMQDLQKWRKSGNRLFRCFVNATKENPASLSC

Download         Length: 375 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 2MW2
PDB 1JW2

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9QBQ5

References