Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/ElaA-DUF1778
Location 71315..72054 Replicon plasmid 5
Accession NZ_LR890193
Organism Klebsiella pneumoniae isolate INF133-sc-2279960

Toxin (Protein)


Gene name tacT Uniprot ID J6I5J9
Locus tag JMX29_RS28080 Protein ID WP_009653238.1
Coordinates 71569..72054 (+) Length 162 a.a.

Antitoxin (Protein)


Gene name tacA Uniprot ID J5VA20
Locus tag JMX29_RS28075 Protein ID WP_009653219.1
Coordinates 71315..71581 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JMX29_RS28045 66917..67675 - 759 WP_023303135.1 hypothetical protein -
JMX29_RS28050 67729..68649 - 921 WP_009651631.1 hypothetical protein -
JMX29_RS28055 68713..69084 - 372 WP_029602876.1 hypothetical protein -
JMX29_RS28060 69225..69914 - 690 WP_009654088.1 hypothetical protein -
JMX29_RS28065 69928..70665 - 738 WP_009654087.1 HupE/UreJ family protein -
JMX29_RS28070 70710..71075 - 366 WP_029602878.1 hypothetical protein -
JMX29_RS28075 71315..71581 + 267 WP_009653219.1 DUF1778 domain-containing protein Antitoxin
JMX29_RS28080 71569..72054 + 486 WP_009653238.1 GNAT family N-acetyltransferase Toxin
JMX29_RS28085 72354..73427 - 1074 WP_048270288.1 IS481 family transposase -
JMX29_RS28090 73488..73649 + 162 WP_032426744.1 type I toxin-antitoxin system Hok family toxin -
JMX29_RS28095 73810..74295 - 486 WP_020277937.1 hypothetical protein -
JMX29_RS28100 74485..74757 + 273 WP_023280873.1 hypothetical protein -
JMX29_RS28105 74754..75104 + 351 WP_020277938.1 hypothetical protein -
JMX29_RS28110 75621..76001 + 381 WP_015632488.1 hypothetical protein -
JMX29_RS28115 76067..76414 + 348 WP_020316654.1 hypothetical protein -
JMX29_RS28120 76502..76732 + 231 WP_020805755.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Conjugative plasmid mcr-10 - 1..120029 120029
- flank IS/Tn - - 72354..73427 1073


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(27-150)

Antitoxin

Vibrio phage ICP1, Orf50

(6-82)


Sequences

Toxin        


Download         Length: 162 a.a.        Molecular weight: 17756.43 Da        Isoelectric Point: 9.9000

>T290241 WP_009653238.1 NZ_LR890193:71569-72054 [Klebsiella pneumoniae]
VGYVTSPEPLSSFHQVAEFISGEAVLDDWLKQRSLKNQATGAARTFVVCKKDTKQVAGFYSLATGSVNHTEATGNLRRNM
PDPIPVIILARLAVDVSFRGKGLGADLLHDAVLRCFRVAENIGVRAIMVHALTEEAKNFYIHHGFKPSQSQPRTLFLRLP
Q

Download         Length: 486 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10123.58 Da        Isoelectric Point: 4.4128

>AT290241 WP_009653219.1 NZ_LR890193:71315-71581 [Klebsiella pneumoniae]
MKSDVQLNLRAKESQRALIDAAAEILHKSRTDFILEMACKAAEDVILDRRVFNFNDEQYAEFIDMIDAPVADDPAIEKLL
ARKPQWDM

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A142I4R1

Antitoxin

Source ID Structure
AlphaFold DB A0A142I4R0

References