Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mosAT/AbiEii-AbiEi
Location 4961892..4963573 Replicon chromosome
Accession NZ_LR890185
Organism Klebsiella pneumoniae isolate INF072-sc-2279995

Toxin (Protein)


Gene name mosT Uniprot ID A0A2L0KL13
Locus tag JMV85_RS24220 Protein ID WP_019704723.1
Coordinates 4961892..4962809 (-) Length 306 a.a.

Antitoxin (Protein)


Gene name mosA Uniprot ID A6TH05
Locus tag JMV85_RS24225 Protein ID WP_004177809.1
Coordinates 4962815..4963573 (-) Length 253 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JMV85_RS24200 4957198..4958718 + 1521 WP_004210021.1 sugar ABC transporter ATP-binding protein -
JMV85_RS24205 4958715..4959713 + 999 WP_002885172.1 ribose ABC transporter permease -
JMV85_RS24210 4959744..4960685 + 942 WP_002885156.1 ABC transporter substrate-binding protein -
JMV85_RS24215 4960760..4961767 + 1008 WP_004178300.1 carbohydrate kinase family protein -
JMV85_RS24220 4961892..4962809 - 918 WP_019704723.1 nucleotidyl transferase AbiEii/AbiGii toxin family protein Toxin
JMV85_RS24225 4962815..4963573 - 759 WP_004177809.1 type IV toxin-antitoxin system AbiEi family antitoxin Antitoxin
JMV85_RS24230 4963659..4964387 - 729 WP_002885152.1 response regulator transcription factor -
JMV85_RS24235 4964660..4966807 + 2148 WP_077625389.1 formate dehydrogenase subunit alpha -
JMV85_RS24240 4966804..4966947 - 144 WP_019704724.1 hypothetical protein -
JMV85_RS24245 4967153..4967839 + 687 WP_004151733.1 sel1 repeat family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Nucleotidyl transferase AbiEii toxin, Type IV TA system

(14-278)

Antitoxin

Transcriptional regulator AbiEi antitoxin, N-terminal domain

(1-93)


Sequences

Toxin        


Download         Length: 306 a.a.        Molecular weight: 34632.07 Da        Isoelectric Point: 5.4707

>T290221 WP_019704723.1 NZ_LR890185:c4962809-4961892 [Klebsiella pneumoniae]
MDIQAPYYRQVALLMQVLPYVAVEREFALKGGTAINLFIRDFPRLSVDIDLAWVPLESRAIALPHIRDALARIAANLQQQ
AGMSAVLQANRSDEMRVIVTTDSAQIKIEVSPVARGTLYPPQEREVVGAVEDVFGYASLPVVSLPDLYGGKLCAALDRQH
PRDFYDVKLLLDAQELDRPIFNGFIAYLLSHNRPLAEVLSPRWKDIAEPFYREFSGMTFETIALEELTAVPNRMIAALKS
CFTQQDVDFLLSFKRGEPDWRLAPEMRIQDLPAVQWKLRNIHQMPAIKRAESLDKLEKVLAEWRS

Download         Length: 918 bp

Antitoxin


Download         Length: 253 a.a.        Molecular weight: 28548.92 Da        Isoelectric Point: 10.0870

>AT290221 WP_004177809.1 NZ_LR890185:c4963573-4962815 [Klebsiella pneumoniae]
MATKLNWLLQNSAPGDVILQSWLSQHAISPSLAFKYAQSGWLKKRGNGVYARAGREPEWNDALACLQNQLAAPVYVAGLS
SLVWQGRSHYLQLKQNQCWLSVENKALLPKWFREFPGVEWIVISGKKLPVLDDRYRVTLDIKGKKLIGSAPELAAYELLS
AVPGTLSFNHAAELFQGLVNLNPRKVEYLLSVSQSVQAKRLYLFFASFYEHGWLKRIDSQKIDLGAGKRQIVENGKFNAQ
YQITVPERFQKE

Download         Length: 759 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2L0KL13

Antitoxin

Source ID Structure
AlphaFold DB A6TH05

References