Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 4800887..4801403 Replicon chromosome
Accession NZ_LR890185
Organism Klebsiella pneumoniae isolate INF072-sc-2279995

Toxin (Protein)


Gene name relE Uniprot ID A0A2A2BGN7
Locus tag JMV85_RS23415 Protein ID WP_009486548.1
Coordinates 4800887..4801171 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A331AB37
Locus tag JMV85_RS23420 Protein ID WP_019704689.1
Coordinates 4801161..4801403 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JMV85_RS23390 4796283..4796591 - 309 WP_004186703.1 PTS sugar transporter subunit IIB -
JMV85_RS23395 4796676..4796792 + 117 WP_161477606.1 hypothetical protein -
JMV85_RS23400 4796852..4797595 + 744 WP_002886905.1 MurR/RpiR family transcriptional regulator -
JMV85_RS23405 4797952..4800090 + 2139 WP_004186701.1 anaerobic ribonucleoside-triphosphate reductase -
JMV85_RS23410 4800419..4800883 + 465 WP_004178375.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
JMV85_RS23415 4800887..4801171 - 285 WP_009486548.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
JMV85_RS23420 4801161..4801403 - 243 WP_019704689.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
JMV85_RS23425 4801481..4803391 - 1911 WP_004152270.1 BglG family transcription antiterminator -
JMV85_RS23430 4803414..4804568 - 1155 WP_019704690.1 lactonase family protein -
JMV85_RS23435 4804635..4805375 - 741 WP_002886899.1 KDGP aldolase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-83)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11125.95 Da        Isoelectric Point: 10.4951

>T290220 WP_009486548.1 NZ_LR890185:c4801171-4800887 [Klebsiella pneumoniae]
MTYELEFDPRARREWQKPGETVKKQFKNKLQQIVQNPRIESTRLSDLPDCYKIKLKASGYRLVYQVRDSVVVVYVIAIGK
REKAAVYHQANKRL

Download         Length: 285 bp

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9044.56 Da        Isoelectric Point: 8.5313

>AT290220 WP_019704689.1 NZ_LR890185:c4801403-4801161 [Klebsiella pneumoniae]
MATLNVRLDDKLKKQAYAVLEKLDMTPTEAVRLLFQYIAENGRMPVKSMTISDGEAALLRTVRERLENPRPGVKVSLDDL

Download         Length: 243 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2A2BGN7

Antitoxin

Source ID Structure
AlphaFold DB A0A331AB37

References