Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/PemK-MazE
Location 1817661..1818208 Replicon chromosome
Accession NC_020520
Organism Ilumatobacter coccineus YM16-304

Toxin (Protein)


Gene name mazF Uniprot ID A0A6C7E792
Locus tag YM304_RS08115 Protein ID WP_015441179.1
Coordinates 1817661..1817993 (-) Length 111 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID A0A6C7E675
Locus tag YM304_RS08120 Protein ID WP_015441180.1
Coordinates 1817990..1818208 (-) Length 73 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
YM304_RS08080 1813148..1813597 - 450 WP_015441172.1 hypothetical protein -
YM304_RS08085 1813737..1814060 - 324 WP_015441173.1 type II toxin-antitoxin system RelE/ParE family toxin -
YM304_RS08090 1814057..1814308 - 252 WP_015441174.1 type II toxin-antitoxin system ParD family antitoxin -
YM304_RS08095 1814593..1815300 - 708 WP_015441175.1 hypothetical protein -
YM304_RS24670 1815323..1815895 + 573 WP_015441176.1 XRE family transcriptional regulator -
YM304_RS08105 1815895..1816716 + 822 WP_015441177.1 EamA family transporter -
YM304_RS08110 1816884..1817537 + 654 WP_015441178.1 FMN-binding negative transcriptional regulator -
YM304_RS08115 1817661..1817993 - 333 WP_015441179.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
YM304_RS08120 1817990..1818208 - 219 WP_015441180.1 antitoxin MazE family protein Antitoxin
YM304_RS08125 1818285..1820651 - 2367 WP_154723366.1 hypothetical protein -
YM304_RS08130 1820712..1821206 - 495 WP_015441183.1 thiol peroxidase -
YM304_RS08135 1821252..1821920 - 669 WP_015441184.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(2-104)

Antitoxin

Antitoxin MazE-like

(12-70)


Sequences

Toxin        


Download         Length: 111 a.a.        Molecular weight: 11788.52 Da        Isoelectric Point: 6.2949

>T29022 WP_015441179.1 NC_020520:c1817993-1817661 [Ilumatobacter coccineus YM16-304]
VRRGEIWTAAAGSGYAGKPRPVVIIQDDLFDATASVTVCAFTTDDTDAPLFRIPVAADEATGIRQPSRLMIDKITTVPRA
KLGERIGRLSDDDMARLARSVIVFLGLATS

Download         Length: 333 bp

>T29022 NC_020520:c1817993-1817661 [Ilumatobacter coccineus YM16-304]
GTGAGGCGCGGCGAGATCTGGACCGCGGCCGCCGGGAGCGGGTACGCCGGCAAACCGCGACCGGTCGTCATCATCCAAGA
CGATCTTTTCGACGCGACTGCGTCGGTCACGGTCTGCGCGTTCACCACCGACGACACCGATGCTCCACTGTTTCGAATAC
CTGTCGCCGCCGACGAGGCGACCGGAATCCGCCAACCGAGCCGGCTCATGATCGACAAGATCACGACCGTTCCTCGTGCG
AAACTTGGCGAACGGATCGGCCGACTATCCGACGACGACATGGCCAGACTCGCACGATCGGTCATCGTGTTCCTCGGCCT
CGCAACATCGTGA

Antitoxin


Download         Length: 73 a.a.        Molecular weight: 8033.81 Da        Isoelectric Point: 6.4583

>AT29022 WP_015441180.1 NC_020520:c1818208-1817990 [Ilumatobacter coccineus YM16-304]
MARQRSTSASAVRVRAHRERLRAQGLRPVQFWVPDVRSPQFAQQAHDQSLAVATSGQESDDQAFIDALGDEE

Download         Length: 219 bp

>AT29022 NC_020520:c1818208-1817990 [Ilumatobacter coccineus YM16-304]
ATGGCTCGTCAACGTTCGACTTCGGCAAGTGCGGTCCGCGTGCGCGCTCATCGCGAGCGGCTCCGCGCGCAGGGCTTGCG
GCCAGTTCAATTCTGGGTGCCCGACGTCCGATCACCCCAGTTCGCACAGCAAGCCCACGATCAATCGCTCGCCGTTGCCA
CGAGCGGCCAGGAGTCTGATGATCAAGCGTTCATCGACGCCCTCGGCGACGAAGAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A6C7E792

Antitoxin

Source ID Structure
AlphaFold DB A0A6C7E675

References