Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 2693671..2695259 Replicon chromosome
Accession NZ_LR890185
Organism Klebsiella pneumoniae isolate INF072-sc-2279995

Toxin (Protein)


Gene name hipA Uniprot ID -
Locus tag JMV85_RS13300 Protein ID WP_019705665.1
Coordinates 2693671..2694993 (-) Length 441 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID -
Locus tag JMV85_RS13305 Protein ID WP_004176198.1
Coordinates 2694993..2695259 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JMV85_RS13285 2688727..2691228 + 2502 WP_019705666.1 fimbrial biogenesis outer membrane usher protein -
JMV85_RS13290 2691216..2692220 + 1005 WP_004184029.1 type 1 fimbrial protein -
JMV85_RS13295 2692362..2693654 + 1293 WP_002904794.1 glycoside hydrolase family 10 protein -
JMV85_RS13300 2693671..2694993 - 1323 WP_019705665.1 type II toxin-antitoxin system HipA family toxin Toxin
JMV85_RS13305 2694993..2695259 - 267 WP_004176198.1 type II toxin-antitoxin system antitoxin HipB Antitoxin
JMV85_RS13310 2695525..2695851 - 327 WP_019705664.1 hydroxyisourate hydrolase -
JMV85_RS13315 2695848..2696348 - 501 WP_019705663.1 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase -
JMV85_RS13320 2696326..2697705 - 1380 WP_004179808.1 purine permease -
JMV85_RS13325 2698051..2699205 + 1155 WP_002904783.1 FAD-dependent urate hydroxylase HpxO -
JMV85_RS13330 2699186..2700109 - 924 WP_019705662.1 LysR family hpxDE operon transcriptional regulator HpxR -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA, N-terminal subdomain 1

(4-103)

Antitoxin

Cro/C1-type helix-turn-helix domain

(13-65)


Sequences

Toxin        


Download         Length: 441 a.a.        Molecular weight: 49155.46 Da        Isoelectric Point: 7.5358

>T290216 WP_019705665.1 NZ_LR890185:c2694993-2693671 [Klebsiella pneumoniae]
MATLTTWMNNVRVGTLTRQANGAHSFRYEEEWLRSPRARPLSLSLPLQYGNITADAVYHYFDNLLPDSPQVRDRIVRRYQ
ARSKQPFDLLAEVGRDSVGAVTLLPPGEEAHLEGLRWQTLDEAQLTALLTAYQSDIPLGMITSQDDFRISVAGAQEKTAL
LRMGEQWCIPQGATPTTHIIKLPIGEIKQPNATLDLRESVDNEYLCLALARELGLAVPEAEIIATPRIRALAVTRFDRRW
AQEGRVLLRLPQEDLCQAFGLPSAMKYESDGGPGIAAIMTFLLGSSEALKDRYDFMKFMVFQWLTGATDGHAKNFSIYLL
PGGSYRLTPFYDIISAFPVLGGTGLHLRDLKLSMGLNATKGRKTEINAIYPRHFLATAKAVNFPREQMLAILQEFAGHVP
QAIESARRTLPADFSSHVWQAITENMLKLHARLQQGLQAL

Download         Length: 1323 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 9936.36 Da        Isoelectric Point: 8.5912

>AT290216 WP_004176198.1 NZ_LR890185:c2695259-2694993 [Klebsiella pneumoniae]
MNSPQIYSPVQLANYLKLLRQQNHWTQDALARRIGIKQATLSNFENHPDKTTLTTLFKILQSLGVVMMLNAKAAETAPAP
DNNTDLDW

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References