Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 4598624..4599140 Replicon chromosome
Accession NZ_LR890184
Organism Klebsiella aerogenes isolate MINF_10B-sc-2280448

Toxin (Protein)


Gene name relE Uniprot ID A0A837JS79
Locus tag JMV66_RS21920 Protein ID WP_045378458.1
Coordinates 4598624..4598908 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID R4Y888
Locus tag JMV66_RS21925 Protein ID WP_002886901.1
Coordinates 4598898..4599140 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JMV66_RS21900 4594039..4594347 - 309 WP_020079792.1 PTS sugar transporter subunit IIB -
JMV66_RS21905 4594609..4595352 + 744 WP_045378461.1 MurR/RpiR family transcriptional regulator -
JMV66_RS21910 4595710..4597848 + 2139 WP_015368566.1 anaerobic ribonucleoside-triphosphate reductase -
JMV66_RS21915 4598156..4598620 + 465 WP_015368567.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
JMV66_RS21920 4598624..4598908 - 285 WP_045378458.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
JMV66_RS21925 4598898..4599140 - 243 WP_002886901.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
JMV66_RS21930 4599218..4601128 - 1911 WP_047040166.1 BglG family transcription antiterminator -
JMV66_RS21935 4601151..4602302 - 1152 WP_047040164.1 lactonase family protein -
JMV66_RS21940 4602369..4603109 - 741 WP_110884137.1 KDGP aldolase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-83)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11145.05 Da        Isoelectric Point: 10.3787

>T290208 WP_045378458.1 NZ_LR890184:c4598908-4598624 [Klebsiella aerogenes]
MTYELEFDPRAWREWQKLGETVKKQFKNKLLQIVQNPRMESARLSDLPDCYKIKLKASGYRLVYQVRDSVVVVYVIAIGK
REKAAVYHQANKRL

Download         Length: 285 bp

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9045.55 Da        Isoelectric Point: 6.3340

>AT290208 WP_002886901.1 NZ_LR890184:c4599140-4598898 [Klebsiella aerogenes]
MATLNVRLDDKLKKEAYAVLEKLDMTPTEAVRLLFQYIAENGRMPVKSMTISDGEAALLRTVRERLENPRPGVKVSLDDL

Download         Length: 243 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A837JS79

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GLP0

References