Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3830801..3831420 Replicon chromosome
Accession NZ_LR890184
Organism Klebsiella aerogenes isolate MINF_10B-sc-2280448

Toxin (Protein)


Gene name Hha Uniprot ID A0A0H3FXE2
Locus tag JMV66_RS18370 Protein ID WP_015367918.1
Coordinates 3831202..3831420 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID A0A837JQD8
Locus tag JMV66_RS18365 Protein ID WP_045381144.1
Coordinates 3830801..3831175 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JMV66_RS18355 3825956..3827155 + 1200 WP_020079451.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
JMV66_RS18360 3827178..3830324 + 3147 WP_015704610.1 multidrug efflux RND transporter permease subunit -
JMV66_RS18365 3830801..3831175 + 375 WP_045381144.1 Hha toxicity modulator TomB Antitoxin
JMV66_RS18370 3831202..3831420 + 219 WP_015367918.1 hemolysin expression modulator Hha Toxin
JMV66_RS18375 3831552..3832115 + 564 WP_201506873.1 maltose O-acetyltransferase -
JMV66_RS18380 3832241..3832705 + 465 WP_015367920.1 YlaC family protein -
JMV66_RS18385 3832680..3834134 - 1455 WP_045381138.1 PLP-dependent aminotransferase family protein -
JMV66_RS18390 3834237..3834947 + 711 WP_045381136.1 GNAT family N-acetyltransferase -
JMV66_RS18395 3834944..3835084 - 141 WP_003859006.1 type B 50S ribosomal protein L36 -
JMV66_RS18400 3835087..3835347 - 261 WP_015367923.1 type B 50S ribosomal protein L31 -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8569.96 Da        Isoelectric Point: 9.4828

>T290207 WP_015367918.1 NZ_LR890184:3831202-3831420 [Klebsiella aerogenes]
MSGKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPTSVWKFIR

Download         Length: 219 bp

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14519.28 Da        Isoelectric Point: 4.9045

>AT290207 WP_045381144.1 NZ_LR890184:3830801-3831175 [Klebsiella aerogenes]
MDEYSPKRHDIAQLRFLCETLYHDCLANLEESNRGWVNDPTSAVNLQLNELIEHIATYALNYKIKYAEDNKLISQLDEYL
DDTFMLFSSYGINTNDLQKWRKSGNRLFRCFVNASRENPVSLSC

Download         Length: 375 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3FXE2

Antitoxin

Source ID Structure
AlphaFold DB A0A837JQD8

References