Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 2578619..2579358 Replicon chromosome
Accession NZ_LR890184
Organism Klebsiella aerogenes isolate MINF_10B-sc-2280448

Toxin (Protein)


Gene name tacT Uniprot ID A0A7D7FM44
Locus tag JMV66_RS12395 Protein ID WP_026612320.1
Coordinates 2578873..2579358 (+) Length 162 a.a.

Antitoxin (Protein)


Gene name tacA Uniprot ID -
Locus tag JMV66_RS12390 Protein ID WP_141238152.1
Coordinates 2578619..2578885 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JMV66_RS12370 2574902..2575519 + 618 WP_201506736.1 response regulator -
JMV66_RS12375 2575615..2576112 + 498 WP_141238151.1 heme-binding protein -
JMV66_RS12380 2576527..2577057 + 531 WP_047041122.1 N-acetyltransferase -
JMV66_RS12385 2577112..2578347 - 1236 WP_182014895.1 MFS transporter -
JMV66_RS12390 2578619..2578885 + 267 WP_141238152.1 DUF1778 domain-containing protein Antitoxin
JMV66_RS12395 2578873..2579358 + 486 WP_026612320.1 GNAT family N-acetyltransferase Toxin
JMV66_RS12400 2579430..2581046 + 1617 WP_182014897.1 FAD-NAD(P)-binding protein -
JMV66_RS12405 2581165..2582265 + 1101 WP_141238153.1 NADH:flavin oxidoreductase/NADH oxidase -
JMV66_RS12410 2582322..2582480 - 159 WP_002903230.1 YqaE/Pmp3 family membrane protein -
JMV66_RS12415 2582741..2583811 + 1071 WP_141238154.1 mannonate dehydratase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(25-151)

Antitoxin

Vibrio phage ICP1, Orf50

(6-82)


Sequences

Toxin        


Download         Length: 162 a.a.        Molecular weight: 17591.26 Da        Isoelectric Point: 8.8793

>T290206 WP_026612320.1 NZ_LR890184:2578873-2579358 [Klebsiella aerogenes]
MGKISAPAPLSSHHQIAEFCCGETVLDQWLKQRGMKNQAQGAARTFVVCKEDSHQVVGFYSLATGSVNHTEATGGLRRNM
PDPIPVIILARLAIDCAFHGQGLGADLLHDALLRSYRVAENVGVRALMVHALTDSAKRFYLHHGFKASTTQERTLFLALP
K

Download         Length: 486 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10113.62 Da        Isoelectric Point: 4.6558

>AT290206 WP_141238152.1 NZ_LR890184:2578619-2578885 [Klebsiella aerogenes]
MKSDIQLNIRAKESQRALIDAAAEILHKSRTDFILEMVCQAAENVILDRRVFNLSDEQYAEFIDMLDAPVEANPALDKLL
ARKPQWEK

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7D7FM44

Antitoxin

Source ID Structure

References