Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | hipBA/HipA-HipB |
Location | 104454..106022 | Replicon | plasmid 3 |
Accession | NZ_LR890183 | ||
Organism | Citrobacter freundii isolate MSB1_1H-sc-2280393 |
Toxin (Protein)
Gene name | hipA | Uniprot ID | - |
Locus tag | JMV71_RS24975 | Protein ID | WP_057521251.1 |
Coordinates | 104715..106022 (+) | Length | 436 a.a. |
Antitoxin (Protein)
Gene name | hipB | Uniprot ID | - |
Locus tag | JMV71_RS24970 | Protein ID | WP_012766359.1 |
Coordinates | 104454..104705 (+) | Length | 84 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
JMV71_RS24945 | 100635..101087 | + | 453 | WP_057521240.1 | hypothetical protein | - |
JMV71_RS24950 | 101103..101705 | - | 603 | WP_057521239.1 | hypothetical protein | - |
JMV71_RS24955 | 101958..102226 | + | 269 | Protein_127 | hypothetical protein | - |
JMV71_RS24960 | 102536..103066 | + | 531 | WP_057521237.1 | hypothetical protein | - |
JMV71_RS24965 | 103069..104073 | + | 1005 | WP_012766358.1 | tyrosine-type recombinase/integrase | - |
JMV71_RS24970 | 104454..104705 | + | 252 | WP_012766359.1 | helix-turn-helix domain-containing protein | Antitoxin |
JMV71_RS24975 | 104715..106022 | + | 1308 | WP_057521251.1 | type II toxin-antitoxin system HipA family toxin | Toxin |
JMV71_RS24980 | 106019..106513 | + | 495 | WP_057521236.1 | hypothetical protein | - |
JMV71_RS24985 | 106688..107626 | - | 939 | WP_057521235.1 | hypothetical protein | - |
JMV71_RS24990 | 107825..109465 | + | 1641 | WP_057521234.1 | PAAR domain-containing protein | - |
JMV71_RS24995 | 109864..110163 | - | 300 | WP_012766365.1 | hypothetical protein | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|---|---|---|---|---|---|---|
- | inside | Non-Mobilizable plasmid | - | - | 1..126853 | 126853 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 436 a.a. Molecular weight: 47869.04 Da Isoelectric Point: 6.1142
>T290200 WP_057521251.1 NZ_LR890183:104715-106022 [Citrobacter freundii]
MQTLTVAMNGEVVGTLYRDNKGAMSFQYAPEWISEPGSRAISMSLPLGHGRITGSEVFNFFSNLLPDSEAIIARMQARFR
VETTHPFDLLASVGRDCVGAIQLYSPDADIPTVMETLAEPLDEAQIEQLLEGYQEAPLGMAEDADFRISIAGAQEKTALL
WYQDRWQRPLGSTPTSHIFKLPIGKIVQNNIDLSESCENEWLCLRIAKAFGFDVANADLATFGKKKVLVVQRFDRRWSKS
GEWLLRLPQEDFCQALGIAPALKYESHGGPGIADAMKLLLGSRFAAKDREQFFKSQILFWMLAAIDGHGKNFSIFIEPAS
SFRMTPLYDVMSAFPIFKSGGIAAQKAKMGMALQGKNRQYSFAMIQPRHFISTAAHVGFPPDTAAQLMLDMATKTEEVVA
TVAAELPAGFPEHISSAIFEGLSSQAAKILKGVAK
MQTLTVAMNGEVVGTLYRDNKGAMSFQYAPEWISEPGSRAISMSLPLGHGRITGSEVFNFFSNLLPDSEAIIARMQARFR
VETTHPFDLLASVGRDCVGAIQLYSPDADIPTVMETLAEPLDEAQIEQLLEGYQEAPLGMAEDADFRISIAGAQEKTALL
WYQDRWQRPLGSTPTSHIFKLPIGKIVQNNIDLSESCENEWLCLRIAKAFGFDVANADLATFGKKKVLVVQRFDRRWSKS
GEWLLRLPQEDFCQALGIAPALKYESHGGPGIADAMKLLLGSRFAAKDREQFFKSQILFWMLAAIDGHGKNFSIFIEPAS
SFRMTPLYDVMSAFPIFKSGGIAAQKAKMGMALQGKNRQYSFAMIQPRHFISTAAHVGFPPDTAAQLMLDMATKTEEVVA
TVAAELPAGFPEHISSAIFEGLSSQAAKILKGVAK
Download Length: 1308 bp
Antitoxin
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Structures
Toxin
Source | ID | Structure |
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Antitoxin
Source | ID | Structure |
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