Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 104454..106022 Replicon plasmid 3
Accession NZ_LR890183
Organism Citrobacter freundii isolate MSB1_1H-sc-2280393

Toxin (Protein)


Gene name hipA Uniprot ID -
Locus tag JMV71_RS24975 Protein ID WP_057521251.1
Coordinates 104715..106022 (+) Length 436 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID -
Locus tag JMV71_RS24970 Protein ID WP_012766359.1
Coordinates 104454..104705 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JMV71_RS24945 100635..101087 + 453 WP_057521240.1 hypothetical protein -
JMV71_RS24950 101103..101705 - 603 WP_057521239.1 hypothetical protein -
JMV71_RS24955 101958..102226 + 269 Protein_127 hypothetical protein -
JMV71_RS24960 102536..103066 + 531 WP_057521237.1 hypothetical protein -
JMV71_RS24965 103069..104073 + 1005 WP_012766358.1 tyrosine-type recombinase/integrase -
JMV71_RS24970 104454..104705 + 252 WP_012766359.1 helix-turn-helix domain-containing protein Antitoxin
JMV71_RS24975 104715..106022 + 1308 WP_057521251.1 type II toxin-antitoxin system HipA family toxin Toxin
JMV71_RS24980 106019..106513 + 495 WP_057521236.1 hypothetical protein -
JMV71_RS24985 106688..107626 - 939 WP_057521235.1 hypothetical protein -
JMV71_RS24990 107825..109465 + 1641 WP_057521234.1 PAAR domain-containing protein -
JMV71_RS24995 109864..110163 - 300 WP_012766365.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..126853 126853


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA, N-terminal subdomain 1

(4-103)

Antitoxin

Cro/C1-type helix-turn-helix domain

(10-64)


Sequences

Toxin        


Download         Length: 436 a.a.        Molecular weight: 47869.04 Da        Isoelectric Point: 6.1142

>T290200 WP_057521251.1 NZ_LR890183:104715-106022 [Citrobacter freundii]
MQTLTVAMNGEVVGTLYRDNKGAMSFQYAPEWISEPGSRAISMSLPLGHGRITGSEVFNFFSNLLPDSEAIIARMQARFR
VETTHPFDLLASVGRDCVGAIQLYSPDADIPTVMETLAEPLDEAQIEQLLEGYQEAPLGMAEDADFRISIAGAQEKTALL
WYQDRWQRPLGSTPTSHIFKLPIGKIVQNNIDLSESCENEWLCLRIAKAFGFDVANADLATFGKKKVLVVQRFDRRWSKS
GEWLLRLPQEDFCQALGIAPALKYESHGGPGIADAMKLLLGSRFAAKDREQFFKSQILFWMLAAIDGHGKNFSIFIEPAS
SFRMTPLYDVMSAFPIFKSGGIAAQKAKMGMALQGKNRQYSFAMIQPRHFISTAAHVGFPPDTAAQLMLDMATKTEEVVA
TVAAELPAGFPEHISSAIFEGLSSQAAKILKGVAK

Download         Length: 1308 bp

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9380.82 Da        Isoelectric Point: 9.8930

>AT290200 WP_012766359.1 NZ_LR890183:104454-104705 [Citrobacter freundii]
MKVTSPSLLAAAVRDQRKLSKLTQSEAAKQVGIKQTTVSDFELRPESTKLETLFKLLAALDLELHVVKRGSTLDDNKVWD
REW

Download         Length: 252 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References