Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) chpSB/-
Location 3877549..3878144 Replicon chromosome
Accession NC_020518
Organism Escherichia coli str. K-12 substr. MDS42

Toxin (Protein)


Gene name chpB Uniprot ID U9XNP6
Locus tag ECMDS42_RS18815 Protein ID WP_000239577.1
Coordinates 3877794..3878144 (+) Length 117 a.a.

Antitoxin (Protein)


Gene name chpS Uniprot ID U9Y2K1
Locus tag ECMDS42_RS18810 Protein ID WP_001223208.1
Coordinates 3877549..3877800 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ECMDS42_RS18800 (ECMDS42_3663) 3873214..3876993 + 3780 WP_000060911.1 autotransporter assembly complex protein TamB -
ECMDS42_RS18805 (ECMDS42_3664) 3876996..3877337 + 342 WP_001219160.1 gamma-glutamylcyclotransferase -
ECMDS42_RS18810 (ECMDS42_3666) 3877549..3877800 + 252 WP_001223208.1 type II toxin-antitoxin system antitoxin ChpS Antitoxin
ECMDS42_RS18815 (ECMDS42_3667) 3877794..3878144 + 351 WP_000239577.1 endoribonuclease toxin ChpB Toxin
ECMDS42_RS18820 (ECMDS42_3668) 3878224..3878754 - 531 WP_000055075.1 inorganic diphosphatase -
ECMDS42_RS18825 (ECMDS42_3669) 3879064..3880020 + 957 WP_000265913.1 galactofuranose ABC transporter substrate-binding protein YtfQ -
ECMDS42_RS18830 (ECMDS42_3670) 3880160..3881662 + 1503 WP_000205805.1 galactofuranose ABC transporter, ATP-binding protein YtfR -
ECMDS42_RS18835 (ECMDS42_3671) 3881676..3882698 + 1023 WP_001313531.1 galactofuranose ABC transporter, ATP-binding protein YtfT -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(8-114)

Antitoxin

SpoVT-AbrB domain

(6-49)


Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 12492.40 Da        Isoelectric Point: 5.5572

>T29020 WP_000239577.1 NC_020518:3877794-3878144 [Escherichia coli str. K-12 substr. MDS42]
MVKKSEFERGDIVLVGFDPASGHEQQGAGRPALVLSVQAFNQLGMTLVAPITQGGNFARYAGFSVPLHCEEGDVHGVVLV
NQVRMMDLHARLAKRIGLAADEVVEEALLRLQAVVE

Download         Length: 351 bp

>T29020 NC_020518:3877794-3878144 [Escherichia coli str. K-12 substr. MDS42]
ATGGTAAAGAAAAGTGAATTTGAACGGGGAGACATTGTGCTGGTTGGCTTTGATCCAGCAAGCGGCCATGAACAGCAAGG
TGCTGGTCGACCTGCGCTTGTGCTCTCCGTTCAAGCCTTTAATCAACTGGGAATGACGCTGGTGGCCCCCATTACGCAGG
GCGGAAATTTTGCCCGTTATGCCGGATTTAGCGTTCCTTTACATTGCGAAGAAGGCGATGTGCACGGCGTGGTGCTGGTG
AATCAGGTGCGGATGATGGATCTACACGCCCGGCTGGCAAAGCGTATTGGTCTGGCTGCGGATGAGGTGGTGGAAGAGGC
GTTATTACGCTTGCAGGCGGTGGTGGAATAA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9271.58 Da        Isoelectric Point: 4.4201

>AT29020 WP_001223208.1 NC_020518:3877549-3877800 [Escherichia coli str. K-12 substr. MDS42]
MRITIKRWGNSAGMVIPNIVMKELNLQPGQSVEAQVSNNQLILTPISRRYSLDELLAQCDMNAAELSEQDVWGKSTPAGD
EIW

Download         Length: 252 bp

>AT29020 NC_020518:3877549-3877800 [Escherichia coli str. K-12 substr. MDS42]
ATGCGTATTACCATAAAAAGATGGGGGAACAGTGCAGGTATGGTCATTCCCAATATCGTAATGAAAGAACTTAACTTACA
GCCGGGGCAGAGCGTGGAGGCGCAAGTGAGCAACAATCAACTGATTCTGACACCCATCTCCAGGCGCTACTCGCTTGATG
AACTGCTGGCACAGTGTGACATGAACGCCGCGGAACTTAGCGAGCAGGATGTCTGGGGTAAATCCACCCCTGCGGGTGAC
GAAATATGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB U9XNP6

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9LQ26

References