Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vagCD/VapC-VagC
Location 53481..54124 Replicon plasmid 2
Accession NZ_LR890182
Organism Citrobacter freundii isolate MSB1_1H-sc-2280393

Toxin (Protein)


Gene name vagD Uniprot ID -
Locus tag JMV71_RS23880 Protein ID WP_121572286.1
Coordinates 53481..53897 (-) Length 139 a.a.

Antitoxin (Protein)


Gene name vagC Uniprot ID -
Locus tag JMV71_RS23885 Protein ID WP_121572285.1
Coordinates 53894..54124 (-) Length 77 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JMV71_RS23860 48790..49548 + 759 WP_047732337.1 DeoR/GlpR family DNA-binding transcription regulator -
JMV71_RS23865 49582..50763 + 1182 WP_121572288.1 MFS transporter -
JMV71_RS23870 50845..51474 + 630 WP_063136851.1 DUF1349 domain-containing protein -
JMV71_RS23875 52265..53335 + 1071 WP_141227224.1 hypothetical protein -
JMV71_RS23880 53481..53897 - 417 WP_121572286.1 type II toxin-antitoxin system VapC family toxin Toxin
JMV71_RS23885 53894..54124 - 231 WP_121572285.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
JMV71_RS23890 54398..55423 + 1026 WP_121572284.1 hypothetical protein -
JMV71_RS23895 55471..56409 - 939 WP_121572283.1 hypothetical protein -
JMV71_RS23900 56981..57292 + 312 WP_121572282.1 hypothetical protein -
JMV71_RS23905 57381..57743 + 363 WP_121572281.1 hypothetical protein -
JMV71_RS23910 57758..58114 + 357 WP_121572348.1 hypothetical protein -
JMV71_RS23915 58111..58890 + 780 WP_201506622.1 site-specific integrase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Conjugative plasmid - - 1..135529 135529


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-129)

Antitoxin

SpoVT-AbrB domain

(7-54)


Sequences

Toxin        


Download         Length: 139 a.a.        Molecular weight: 15133.65 Da        Isoelectric Point: 6.2225

>T290199 WP_121572286.1 NZ_LR890182:c53897-53481 [Citrobacter freundii]
VNKTYMLDTCICSFIMREQPEAVLKHLEQAVLRNQRIVIPVITYAEMRFGATGPKVSPRHIELVDAFCARLDAILPWDSA
AVDATTEIKVALRLAGTPIGPNDTAIAGHAIAAGVVLVTNNVREFERVPGLVLEDWVK

Download         Length: 417 bp

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 8779.86 Da        Isoelectric Point: 4.1211

>AT290199 WP_121572285.1 NZ_LR890182:c54124-53894 [Citrobacter freundii]
MRTVSIFKNGNNRAIRLPRDLDFEGVSELEIVREGDSIILRPVPPTWDSFLELEKADPDFMAEREDVVTDEGRFDL

Download         Length: 231 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References