290198

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/LOTUS_5_Limkain_b1(toxin)
Location 4733251..4733867 Replicon chromosome
Accession NZ_LR890181
Organism Citrobacter freundii isolate MSB1_1H-sc-2280393

Toxin (Protein)


Gene name vapC Uniprot ID A0A0J1MQ96
Locus tag JMV71_RS22780 Protein ID WP_003028682.1
Coordinates 4733251..4733625 (-) Length 125 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID A0A6B5NTK4
Locus tag JMV71_RS22785 Protein ID WP_043018956.1
Coordinates 4733625..4733867 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JMV71_RS22765 4730754..4731656 + 903 WP_106107909.1 formate dehydrogenase O subunit beta -
JMV71_RS22770 4731653..4732288 + 636 WP_003028686.1 formate dehydrogenase cytochrome b556 subunit -
JMV71_RS22775 4732285..4733214 + 930 WP_003028685.1 formate dehydrogenase accessory protein FdhE -
JMV71_RS22780 4733251..4733625 - 375 WP_003028682.1 type II toxin-antitoxin system VapC family toxin Toxin
JMV71_RS22785 4733625..4733867 - 243 WP_043018956.1 ribbon-helix-helix domain-containing protein Antitoxin
JMV71_RS22790 4734073..4734981 + 909 WP_119174684.1 alpha/beta hydrolase -
JMV71_RS22795 4735132..4736073 - 942 WP_003825286.1 fatty acid biosynthesis protein FabY -
JMV71_RS22800 4736118..4736555 - 438 WP_003028671.1 D-tyrosyl-tRNA(Tyr) deacylase -
JMV71_RS22805 4736552..4737424 - 873 WP_003840437.1 virulence factor BrkB family protein -
JMV71_RS22810 4737418..4738017 - 600 WP_016151258.1 glucose-1-phosphatase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(7-112)

Antitoxin

Ribbon-helix-helix protein, CopG

(13-47)


Sequences

Toxin        


Download         Length: 125 a.a.        Molecular weight: 13674.89 Da        Isoelectric Point: 9.5622

>T290198 WP_003028682.1 NZ_LR890181:c4733625-4733251 [Citrobacter freundii]
MVKGSALFDTNILIDLFSGRNEAKLAIETWPPQNAISLITWMEVMVGAKKYHQEARTRVALGAFNVIGVSQDIAERSVSI
RQEYGMKLPDAIILATAQIHRLTLVTRNTKDFAGLSGVVTPYTL

Download         Length: 375 bp

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9451.75 Da        Isoelectric Point: 4.3437

>AT290198 WP_043018956.1 NZ_LR890181:c4733867-4733625 [Citrobacter freundii]
MMAGMDMGRILLDLSDEVIKRLDDLKVQRNLPRAELLREAVEQYLERQDQAETTISRALGLWQGCEEDGVEYQRKLREEW

Download         Length: 243 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0J1MQ96

Antitoxin

Source ID Structure
AlphaFold DB A0A6B5NTK4

References