Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 4325993..4326509 Replicon chromosome
Accession NZ_LR890181
Organism Citrobacter freundii isolate MSB1_1H-sc-2280393

Toxin (Protein)


Gene name relE Uniprot ID A0A0D7LMW6
Locus tag JMV71_RS20880 Protein ID WP_003839578.1
Coordinates 4325993..4326277 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A0J1MV10
Locus tag JMV71_RS20885 Protein ID WP_003839576.1
Coordinates 4326267..4326509 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JMV71_RS20865 4322240..4322824 + 585 WP_200020370.1 fructose PTS transporter subunit IIA -
JMV71_RS20870 4323202..4325340 + 2139 WP_003025782.1 anaerobic ribonucleoside-triphosphate reductase -
JMV71_RS20875 4325525..4325989 + 465 WP_032937736.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
JMV71_RS20880 4325993..4326277 - 285 WP_003839578.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
JMV71_RS20885 4326267..4326509 - 243 WP_003839576.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
JMV71_RS20890 4326587..4328500 - 1914 WP_003844930.1 BglG family transcription antiterminator -
JMV71_RS20895 4328522..4329262 - 741 WP_003025772.1 KDGP aldolase family protein -
JMV71_RS20900 4329259..4330377 - 1119 WP_048219848.1 DgaE family pyridoxal phosphate-dependent ammonia lyase -
JMV71_RS20905 4330361..4331494 - 1134 WP_016149471.1 amidohydrolase/deacetylase family metallohydrolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-82)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-69)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 10866.68 Da        Isoelectric Point: 10.0482

>T290197 WP_003839578.1 NZ_LR890181:c4326277-4325993 [Citrobacter freundii]
MTYELEFDPRALKEWHKLGDTVKAQFKKKLADVLLNPRIDSARLNGLPDCYKIKLKSSGYRLVYQVRDEVVTVFVVAVGK
REHSAVYLDANKRL

Download         Length: 285 bp

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 8961.34 Da        Isoelectric Point: 5.0651

>AT290197 WP_003839576.1 NZ_LR890181:c4326509-4326267 [Citrobacter freundii]
MATLNVRLDDKLKNEAYAVLEKLNITPTEAVRLLFQYVAETGRMPVKTVTVSDSEDTLIQTVRERLASPQKGIKVSLDDL

Download         Length: 243 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0D7LMW6

Antitoxin

Source ID Structure
AlphaFold DB A0A0J1MV10

References