Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/UPF0150(antitoxin)
Location 2448843..2449482 Replicon chromosome
Accession NZ_LR890181
Organism Citrobacter freundii isolate MSB1_1H-sc-2280393

Toxin (Protein)


Gene name hicA Uniprot ID A0A8B5QF36
Locus tag JMV71_RS11980 Protein ID WP_003020221.1
Coordinates 2448843..2449019 (+) Length 59 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag JMV71_RS11985 Protein ID WP_123924900.1
Coordinates 2449066..2449482 (+) Length 139 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JMV71_RS11960 2445621..2445851 - 231 WP_003020233.1 DUF2554 family protein -
JMV71_RS11965 2446041..2446166 - 126 WP_003020230.1 DUF2474 domain-containing protein -
JMV71_RS11970 2446166..2447176 - 1011 WP_003020227.1 cytochrome d ubiquinol oxidase subunit II -
JMV71_RS11975 2447176..2448579 - 1404 WP_003020224.1 cytochrome ubiquinol oxidase subunit I -
JMV71_RS11980 2448843..2449019 + 177 WP_003020221.1 type II toxin-antitoxin system HicA family toxin Toxin
JMV71_RS11985 2449066..2449482 + 417 WP_123924900.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
JMV71_RS11990 2449575..2450984 + 1410 WP_003836140.1 PLP-dependent aminotransferase family protein -
JMV71_RS11995 2451312..2452457 + 1146 WP_003020212.1 ABC transporter substrate-binding protein -
JMV71_RS12000 2452474..2453490 + 1017 WP_003020210.1 ABC transporter ATP-binding protein -
JMV71_RS12005 2453491..2454435 + 945 WP_003843727.1 ABC transporter permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(5-57)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(3-65)


Sequences

Toxin        


Download         Length: 59 a.a.        Molecular weight: 6769.80 Da        Isoelectric Point: 11.2510

>T290194 WP_003020221.1 NZ_LR890181:2448843-2449019 [Citrobacter freundii]
VKQSEFRRWLESQGVAVTNGSNHLKLRYQGRRSVMPRHPGDEIKEALRKAIIKQLDLQ

Download         Length: 177 bp

Antitoxin


Download         Length: 139 a.a.        Molecular weight: 15126.36 Da        Isoelectric Point: 4.5716

>AT290194 WP_123924900.1 NZ_LR890181:2449066-2449482 [Citrobacter freundii]
MRYPVTLTPAVEGGFVVSFPDIPEALTQGNTRHDALQAAQAALITAFEFYFDDNEAIPLPSAVSAEDDYVEIPLSVASKV
LLLNAFLESKITQQELANRIGRPKQEITRLFDLKHTTKIDAVQIAARALGKELALTML

Download         Length: 417 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A8B5QF36

Antitoxin

Source ID Structure

References