Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yfjZ-ypjF/CbtA-CbeA
Location 1185958..1186625 Replicon chromosome
Accession NZ_LR890181
Organism Citrobacter freundii isolate MSB1_1H-sc-2280393

Toxin (Protein)


Gene name ypjF Uniprot ID A0A4Q2R4P3
Locus tag JMV71_RS05685 Protein ID WP_032733644.1
Coordinates 1185958..1186287 (-) Length 110 a.a.

Antitoxin (Protein)


Gene name yfjZ Uniprot ID -
Locus tag JMV71_RS05690 Protein ID WP_119174477.1
Coordinates 1186308..1186625 (-) Length 106 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JMV71_RS05680 1181689..1185231 - 3543 WP_119174478.1 inverse autotransporter beta domain-containing protein -
JMV71_RS05685 1185958..1186287 - 330 WP_032733644.1 TA system toxin CbtA family protein Toxin
JMV71_RS05690 1186308..1186625 - 318 WP_119174477.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
JMV71_RS05695 1186644..1186865 - 222 WP_047028248.1 DUF987 domain-containing protein -
JMV71_RS05700 1186874..1187356 - 483 WP_087900482.1 RadC family protein -
JMV71_RS05705 1187365..1187823 - 459 WP_119174476.1 antirestriction protein -
JMV71_RS05710 1187909..1188145 - 237 WP_048339400.1 DUF905 domain-containing protein -
JMV71_RS05715 1188223..1188633 - 411 WP_119174475.1 hypothetical protein -
JMV71_RS05720 1188700..1189137 - 438 WP_057059560.1 hypothetical protein -
JMV71_RS05725 1189179..1189715 - 537 WP_064279067.1 DUF4339 domain-containing protein -
JMV71_RS05730 1189741..1190451 - 711 WP_119174474.1 DeoR family transcriptional regulator -
JMV71_RS05735 1190660..1191484 - 825 WP_119174473.1 DUF945 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-108)

Antitoxin

Antitoxin CbeA

(5-104)


Sequences

Toxin        


Download         Length: 110 a.a.        Molecular weight: 12353.33 Da        Isoelectric Point: 9.5741

>T290189 WP_032733644.1 NZ_LR890181:c1186287-1185958 [Citrobacter freundii]
MKTLPATISRATKPCLSPVAVWQMLLTHLLEQHYGLTLNDTPFSDKTVIQEHINAGVSLSDAVNFLVEKYELVRIDRKGF
SWQEQTPYISVVDILRARRSTGLLKTNVK

Download         Length: 330 bp

Antitoxin


Download         Length: 106 a.a.        Molecular weight: 11967.57 Da        Isoelectric Point: 6.8412

>AT290189 WP_119174477.1 NZ_LR890181:c1186625-1186308 [Citrobacter freundii]
MSNITWGLQRDITPRLGVRLVQEGNRLYYLADRASITGKFSDAECRKLDETFPHFISQMESMLTTGEMNPRHAHCVTLYH
NGFTCEADTLGSCGYVYIAVYPTQR

Download         Length: 318 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A4Q2R4P3

Antitoxin

Source ID Structure

References