290186

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/-
Location 251960..252591 Replicon chromosome
Accession NZ_LR890181
Organism Citrobacter freundii isolate MSB1_1H-sc-2280393

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag JMV71_RS01165 Protein ID WP_201506468.1
Coordinates 251960..252235 (+) Length 92 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID A0A0J1MMS0
Locus tag JMV71_RS01170 Protein ID WP_003837808.1
Coordinates 252232..252591 (+) Length 120 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JMV71_RS01155 248011..250758 + 2748 WP_032937231.1 ribosome-associated ATPase/putative transporter RbbA -
JMV71_RS01160 250758..251882 + 1125 WP_003837801.1 ABC transporter permease -
JMV71_RS01165 251960..252235 + 276 WP_201506468.1 type II toxin-antitoxin system HicA family toxin Toxin
JMV71_RS01170 252232..252591 + 360 WP_003837808.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
JMV71_RS01175 252704..253105 - 402 WP_003023387.1 nickel-responsive transcriptional regulator NikR -
JMV71_RS01180 253155..253733 - 579 WP_003837810.1 4'-phosphopantetheinyl transferase AcpT -
JMV71_RS01185 253796..254845 - 1050 WP_003023393.1 AI-2E family transporter -
JMV71_RS01190 254979..256196 + 1218 WP_016151126.1 MFS transporter -
JMV71_RS01195 256200..256757 - 558 WP_003837816.1 DcrB family lipoprotein -
JMV71_RS01200 256830..257495 - 666 WP_119174639.1 7-cyano-7-deazaguanine/7-aminomethyl-7- deazaguanine transporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(30-80)

Antitoxin

Uncharacterised protein family HicB

(60-112)


Sequences

Toxin        


Download         Length: 92 a.a.        Molecular weight: 10152.85 Da        Isoelectric Point: 10.8528

>T290186 WP_201506468.1 NZ_LR890181:251960-252235 [Citrobacter freundii]
MKEKVLSLRKKQKNTLDQLFKAPTPQGIKWSEIESLIKALGGEIKEGRGSRCKFLLNKSIASFHRPHPSPDTDKGAVENV
RGWLTSIGVKP

Download         Length: 276 bp

Antitoxin


Download         Length: 120 a.a.        Molecular weight: 13198.98 Da        Isoelectric Point: 4.5462

>AT290186 WP_003837808.1 NZ_LR890181:252232-252591 [Citrobacter freundii]
MIKPKTPNSMEIAGQPAVINYVPELNAFRGKFLGLSGYCDFVSDSIQGLQKEGEISLREYLDDCSAAGIEPYANPEKLKT
FTLRYPESFGERLSFAAAEEQVSVNTWIIETLSKSLKQA

Download         Length: 360 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A0J1MMS0

References