Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) phd-doc/Doc-Phd
Location 74685..75286 Replicon plasmid 2
Accession NZ_LR883966
Organism Escherichia coli isolate 2016-17-550

Toxin (Protein)


Gene name doc Uniprot ID U9YA20
Locus tag JMV10_RS22845 Protein ID WP_001216045.1
Coordinates 74685..75065 (-) Length 127 a.a.

Antitoxin (Protein)


Gene name phd Uniprot ID U9YQH9
Locus tag JMV10_RS22850 Protein ID WP_001190712.1
Coordinates 75065..75286 (-) Length 74 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JMV10_RS22820 70893..71777 - 885 WP_000058717.1 EamA family transporter -
JMV10_RS22825 71915..72322 - 408 WP_001214976.1 cysteine hydrolase -
JMV10_RS22830 72311..74062 + 1752 Protein_75 Tn3-like element TnAs1 family transposase -
JMV10_RS22835 74096..74473 - 378 Protein_76 hypothetical protein -
JMV10_RS22840 74501..74680 - 180 WP_000113019.1 hypothetical protein -
JMV10_RS22845 74685..75065 - 381 WP_001216045.1 type II toxin-antitoxin system death-on-curing family toxin Toxin
JMV10_RS22850 75065..75286 - 222 WP_001190712.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
JMV10_RS22855 75469..77025 + 1557 WP_016231378.1 type I restriction-modification system subunit M -
JMV10_RS22860 77022..78257 + 1236 WP_059338147.1 restriction endonuclease subunit S -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Mobilizable plasmid qnrS1 / blaTEM-1B / tet(A) - 1..104732 104732


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Death on curing protein

(3-120)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-51)


Sequences

Toxin        


Download         Length: 127 a.a.        Molecular weight: 13588.29 Da        Isoelectric Point: 5.1514

>T290185 WP_001216045.1 NZ_LR883966:c75065-74685 [Escherichia coli]
MRHISPEELIALHDANISRYGGLPGMSDPGRAEAIIGRVQARVAYEEITDLFEVSATYLVATARGHIFNDANKRTALNSA
LLFLRRNGVQVFDSPELADLTVGAATGEISVSSVADTLRRLYGSAE

Download         Length: 381 bp

Antitoxin


Download         Length: 74 a.a.        Molecular weight: 8133.10 Da        Isoelectric Point: 4.7708

>AT290185 WP_001190712.1 NZ_LR883966:c75286-75065 [Escherichia coli]
MQSINFRTARGNLSEVLNNVEAGEEVEITRRGREPAVIVSKATFEAYKKAALDAEFASLFDTLDSTNKELVNR

Download         Length: 222 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A829CLP7

Antitoxin

Source ID Structure
AlphaFold DB A0A829CJB6

References