Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-YafN
Location 40057..40592 Replicon plasmid 2
Accession NZ_LR883966
Organism Escherichia coli isolate 2016-17-550

Toxin (Protein)


Gene name relE Uniprot ID A0A0K4CX11
Locus tag JMV10_RS22660 Protein ID WP_000222771.1
Coordinates 40057..40344 (-) Length 96 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID T1PXV2
Locus tag JMV10_RS22665 Protein ID WP_001139206.1
Coordinates 40341..40592 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JMV10_RS22645 35700..39197 + 3498 WP_201488718.1 autotransporter outer membrane beta-barrel domain-containing protein -
JMV10_RS22650 39372..39577 - 206 Protein_39 transposase -
JMV10_RS22655 39567..39767 + 201 WP_000896262.1 DUF839 domain-containing protein -
JMV10_RS22660 40057..40344 - 288 WP_000222771.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
JMV10_RS22665 40341..40592 - 252 WP_001139206.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
JMV10_RS22670 41205..43022 + 1818 Protein_43 helicase -
JMV10_RS22675 43056..43496 + 441 WP_023352064.1 hypothetical protein -
JMV10_RS22680 43493..43741 + 249 WP_000747846.1 hypothetical protein -
JMV10_RS22685 43780..44501 - 722 Protein_46 AraC family transcriptional regulator -
JMV10_RS22690 44735..45424 + 690 WP_001615575.1 EAL domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Mobilizable plasmid qnrS1 / blaTEM-1B / tet(A) - 1..104732 104732


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-83)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 11116.17 Da        Isoelectric Point: 10.5833

>T290184 WP_000222771.1 NZ_LR883966:c40344-40057 [Escherichia coli]
MTYTVKFRDDALKEWLRLDKTIQQQFAKKLKKCSENPHIASAKLRGLKDCYKIKLRASGFRLVYQVIDDMLIIAVVAVGK
RERSNVYHLASERMK

Download         Length: 288 bp

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9171.39 Da        Isoelectric Point: 4.0927

>AT290184 WP_001139206.1 NZ_LR883966:c40592-40341 [Escherichia coli]
MPSIILSDTSASVSELKKNPMATVSAGEGYPVAILNRNQPAFYCVPAELYERMLDALDDQELVKLVTERSSQPLHDVDLD
SYL

Download         Length: 252 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0K4CX11

Antitoxin

Source ID Structure
AlphaFold DB T1PXV2

References