Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 4310978..4311603 Replicon chromosome
Accession NZ_LR883965
Organism Escherichia coli isolate 2016-17-550

Toxin (Protein)


Gene name vapC Uniprot ID U9YZ02
Locus tag JMV10_RS20610 Protein ID WP_000911329.1
Coordinates 4311205..4311603 (+) Length 133 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID U9XQV3
Locus tag JMV10_RS20605 Protein ID WP_000450524.1
Coordinates 4310978..4311205 (+) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JMV10_RS20580 4306780..4307250 - 471 WP_001068682.1 thioredoxin-dependent thiol peroxidase -
JMV10_RS20585 4307250..4307822 - 573 WP_000176187.1 glycine cleavage system transcriptional repressor -
JMV10_RS20590 4307968..4308846 + 879 WP_001295469.1 4-hydroxy-tetrahydrodipicolinate synthase -
JMV10_RS20595 4308863..4309897 + 1035 WP_001297320.1 outer membrane protein assembly factor BamC -
JMV10_RS20600 4310110..4310823 + 714 WP_001295467.1 phosphoribosylaminoimidazolesuccinocarboxamide synthase -
JMV10_RS20605 4310978..4311205 + 228 WP_000450524.1 toxin-antitoxin system antitoxin VapB Antitoxin
JMV10_RS20610 4311205..4311603 + 399 WP_000911329.1 tRNA(fMet)-specific endonuclease VapC Toxin
JMV10_RS20615 4311750..4312613 + 864 WP_201488683.1 neutral zinc metallopeptidase -
JMV10_RS20620 4312628..4314643 + 2016 WP_032254558.1 tRNA cytosine(34) acetyltransferase TmcA -
JMV10_RS20625 4314717..4315415 + 699 WP_000679823.1 esterase -
JMV10_RS20630 4315525..4315725 - 201 WP_000383836.1 YpfN family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-125)

Antitoxin

SpoVT-AbrB domain

(7-52)


Sequences

Toxin        


Download         Length: 133 a.a.        Molecular weight: 14924.23 Da        Isoelectric Point: 8.5325

>T290183 WP_000911329.1 NZ_LR883965:4311205-4311603 [Escherichia coli]
MLKFMLDTNICIFTIKNKPVHVRERFNLNSGRMCISSVTLMELIYGAEKSQMPERNLAVIEGFVSRLEVLDYDSAAATHT
GQIRAELARQGRPVGPFDQMIAGHARSRGLIVVTNNTREFERVAGIRLEDWS

Download         Length: 399 bp

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8498.61 Da        Isoelectric Point: 4.3867

>AT290183 WP_000450524.1 NZ_LR883965:4310978-4311205 [Escherichia coli]
METTVFLSNRSQAVRLPKAVALPEDVKKVEIIAIGRTRIITPAGESWDSWFDGENVSADFMDIRDQPAMQERESF

Download         Length: 228 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0XW84

Antitoxin

Source ID Structure
AlphaFold DB A0A829CM33

References