Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 3847142..3847796 Replicon chromosome
Accession NZ_LR883965
Organism Escherichia coli isolate 2016-17-550

Toxin (Protein)


Gene name cptA Uniprot ID F4NJ21
Locus tag JMV10_RS18350 Protein ID WP_000244772.1
Coordinates 3847389..3847796 (+) Length 136 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID S1PPB1
Locus tag JMV10_RS18345 Protein ID WP_000354046.1
Coordinates 3847142..3847408 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JMV10_RS18320 3842311..3843054 + 744 WP_000951961.1 SDR family oxidoreductase -
JMV10_RS18325 3843111..3844544 - 1434 WP_001344773.1 6-phospho-beta-glucosidase BglA -
JMV10_RS18330 3844589..3844900 + 312 WP_001182954.1 N(4)-acetylcytidine aminohydrolase -
JMV10_RS18335 3845064..3845723 + 660 WP_000250274.1 hemolysin III family protein -
JMV10_RS18340 3845919..3846899 - 981 WP_000886095.1 tRNA-modifying protein YgfZ -
JMV10_RS18345 3847142..3847408 + 267 WP_000354046.1 FAD assembly factor SdhE Antitoxin
JMV10_RS18350 3847389..3847796 + 408 WP_000244772.1 protein YgfX Toxin
JMV10_RS18355 3847836..3848357 - 522 WP_001055874.1 flavodoxin FldB -
JMV10_RS18360 3848469..3849365 + 897 WP_000806638.1 site-specific tyrosine recombinase XerD -
JMV10_RS18365 3849390..3850100 + 711 WP_000715214.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
JMV10_RS18370 3850106..3851839 + 1734 WP_000813215.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 136 a.a.        Molecular weight: 16048.02 Da        Isoelectric Point: 11.2511

>T290181 WP_000244772.1 NZ_LR883965:3847389-3847796 [Escherichia coli]
VVLWQSDLRVSWRAQWLSLLIHGLVAAVILLMPWPLSYTPLWMVLLSLVVFDCVRSQRRINARQGEIRLLMDGRLRWQGQ
EWCIVKAPWMIKSGMMLRLRSDGGKRQHLWLAADSMDEAEWRDLRRILLQQETQR

Download         Length: 408 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10547.12 Da        Isoelectric Point: 5.1599

>AT290181 WP_000354046.1 NZ_LR883965:3847142-3847408 [Escherichia coli]
MDINNKARIHWACRRGMRELDISIMPFFEHEYDSLSDDEKRIFIRLLECDDPDLFNWLMNHGKPADAELEMMVRLIQTRN
RERGPVAI

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0XYB4

Antitoxin

Source ID Structure
PDB 6B58
PDB 1X6I
PDB 1X6J
PDB 6C12
AlphaFold DB A0A7U9QD57

References