Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/-
Location 3256034..3256665 Replicon chromosome
Accession NZ_LR883965
Organism Escherichia coli isolate 2016-17-550

Toxin (Protein)


Gene name hicA Uniprot ID U9Y2A7
Locus tag JMV10_RS15355 Protein ID WP_001259385.1
Coordinates 3256034..3256309 (+) Length 92 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID Q31VE4
Locus tag JMV10_RS15360 Protein ID WP_000593554.1
Coordinates 3256306..3256665 (+) Length 120 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JMV10_RS15340 3251038..3252105 + 1068 WP_000361485.1 HlyD family secretion protein -
JMV10_RS15345 3252102..3254837 + 2736 WP_094315445.1 ribosome-associated ATPase/putative transporter RbbA -
JMV10_RS15350 3254837..3255961 + 1125 WP_001314210.1 ABC transporter permease -
JMV10_RS15355 3256034..3256309 + 276 WP_001259385.1 type II toxin-antitoxin system HicA family toxin Toxin
JMV10_RS15360 3256306..3256665 + 360 WP_000593554.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
JMV10_RS15365 3256715..3257575 - 861 WP_001131783.1 class II aldolase -
JMV10_RS15370 3257607..3257876 - 270 WP_000933060.1 HPr family phosphocarrier protein -
JMV10_RS15375 3257866..3259374 - 1509 WP_001298718.1 carbohydrate kinase -
JMV10_RS15380 3259367..3260725 - 1359 WP_001298729.1 PTS galactitol transporter subunit IIC -
JMV10_RS15385 3260802..3261083 - 282 WP_000084022.1 PTS sugar transporter subunit IIB -
JMV10_RS15390 3261080..3261553 - 474 WP_001161553.1 PTS sugar transporter subunit IIA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 3249050..3262924 13874


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(30-80)

Antitoxin

Uncharacterised protein family HicB

(60-112)


Sequences

Toxin        


Download         Length: 92 a.a.        Molecular weight: 10199.94 Da        Isoelectric Point: 10.7076

>T290178 WP_001259385.1 NZ_LR883965:3256034-3256309 [Escherichia coli]
MRTKVQALRKKQKNTLDQIFKTPVPQGIKWSDIESLVKALGGEIKEGRGSRCKFILNMSVACFHRPHPSPDTDKGAVESV
RDWLLSIGVKP

Download         Length: 276 bp

Antitoxin


Download         Length: 120 a.a.        Molecular weight: 13359.25 Da        Isoelectric Point: 4.8838

>AT290178 WP_000593554.1 NZ_LR883965:3256306-3256665 [Escherichia coli]
MIKLKTPNSMEIAGQPAVITYVPELNAFRGKFLGLSGYCDFVSDSIQGLQKEGELSLLEYLEDCKAAGIEPYARTEKIKT
FTLRYPESLSERLNNAAAQQQVSVNTYIIETLNERLNHL

Download         Length: 360 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A4P7TTW8

Antitoxin

Source ID Structure
AlphaFold DB A0A6H2GM94

References