290173

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) itaRT/DUF1778(antitoxin)
Location 1728400..1729237 Replicon chromosome
Accession NZ_LR883965
Organism Escherichia coli isolate 2016-17-550

Toxin (Protein)


Gene name itaT Uniprot ID Q3Z4X7
Locus tag JMV10_RS08300 Protein ID WP_000227784.1
Coordinates 1728695..1729237 (+) Length 181 a.a.

Antitoxin (Protein)


Gene name itaR Uniprot ID A0A3T7ZCX8
Locus tag JMV10_RS08295 Protein ID WP_001442339.1
Coordinates 1728400..1728711 (+) Length 104 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JMV10_RS08270 1723420..1724367 + 948 WP_001239441.1 cytochrome o ubiquinol oxidase subunit II -
JMV10_RS08275 1724389..1726380 + 1992 WP_000467180.1 cytochrome o ubiquinol oxidase subunit I -
JMV10_RS08280 1726370..1726984 + 615 WP_000179819.1 cytochrome o ubiquinol oxidase subunit III -
JMV10_RS08285 1726984..1727313 + 330 WP_000019869.1 cytochrome o ubiquinol oxidase subunit IV -
JMV10_RS08290 1727325..1728215 + 891 WP_000971336.1 heme o synthase -
JMV10_RS08295 1728400..1728711 + 312 WP_001442339.1 DUF1778 domain-containing protein Antitoxin
JMV10_RS08300 1728695..1729237 + 543 WP_000227784.1 GNAT family N-acetyltransferase Toxin
JMV10_RS08305 1729293..1730228 - 936 WP_001365761.1 sel1 repeat family protein -
JMV10_RS08310 1730636..1732000 + 1365 WP_001000978.1 MFS transporter -
JMV10_RS08315 1732128..1732619 - 492 WP_001138904.1 nucleotide binding protein YajQ -
JMV10_RS08320 1732787..1733698 + 912 WP_000705849.1 2-dehydropantoate 2-reductase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(68-156)

Antitoxin

Vibrio phage ICP1, Orf50

(19-96)


Sequences

Toxin        


Download         Length: 181 a.a.        Molecular weight: 19805.02 Da        Isoelectric Point: 8.3395

>T290173 WP_000227784.1 NZ_LR883965:1728695-1729237 [Escherichia coli]
MVDKHEEITLPIVLSCNYQSDITYPGQKQFDCGNPVIDKFVRASLKKSVRNSDCAAKALIDRQSGELIGICTFTAYSLEK
QRVSGVLQGSQPSEIGVVRLVMLGVARKYQKRGFGQDLLCDFFEHVKIIHQALPIKGVYLDADPAAINFYARLGFVQLSA
TPNAFGAVPMFLAIQHILAA

Download         Length: 543 bp

Antitoxin


Download         Length: 104 a.a.        Molecular weight: 11358.04 Da        Isoelectric Point: 10.4825

>AT290173 WP_001442339.1 NZ_LR883965:1728400-1728711 [Escherichia coli]
MPGKTATLPDVDKTLKNARVEIKTSPDAKNKLREAAQAVGVDLSAFILSAAMERAESVLDNQRRRELSNQSWELMNQLIA
EPAQPTLALKALMKRKNSDGRQA

Download         Length: 312 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 7BYY

Antitoxin

Source ID Structure
AlphaFold DB A0A3T7ZCX8

References