Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/UPF0150(antitoxin)
Location 675689..676327 Replicon chromosome
Accession NZ_LR883965
Organism Escherichia coli isolate 2016-17-550

Toxin (Protein)


Gene name hicA Uniprot ID S1F9G9
Locus tag JMV10_RS03275 Protein ID WP_000813794.1
Coordinates 676151..676327 (-) Length 59 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag JMV10_RS03270 Protein ID WP_001270285.1
Coordinates 675689..676105 (-) Length 139 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JMV10_RS03250 670841..671782 - 942 WP_001251315.1 ABC transporter permease -
JMV10_RS03255 671783..672796 - 1014 WP_000220396.1 ABC transporter ATP-binding protein -
JMV10_RS03260 672814..673959 - 1146 WP_000047456.1 ABC transporter substrate-binding protein -
JMV10_RS03265 674204..675610 - 1407 WP_000760589.1 PLP-dependent aminotransferase family protein -
JMV10_RS03270 675689..676105 - 417 WP_001270285.1 type II toxin-antitoxin system antitoxin HicB Antitoxin
JMV10_RS03275 676151..676327 - 177 WP_000813794.1 type II toxin-antitoxin system mRNA interferase toxin HicA Toxin
JMV10_RS03280 676549..676779 + 231 Protein_644 DUF2554 family protein -
JMV10_RS03285 676871..678832 - 1962 WP_032255020.1 23S rRNA 5-hydroxycytidine C2501 synthase -
JMV10_RS03290 678905..679441 - 537 WP_000429141.1 DNA-binding transcriptional regulator SutR -
JMV10_RS03295 679494..680708 + 1215 WP_071601296.1 BenE family transporter YdcO -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(5-57)

Antitoxin

Cro/C1-type helix-turn-helix domain

(88-134)


Sequences

Toxin        


Download         Length: 59 a.a.        Molecular weight: 6749.83 Da        Isoelectric Point: 11.2298

>T290171 WP_000813794.1 NZ_LR883965:c676327-676151 [Escherichia coli]
VKQSEFRRWLESQGVDVANGSNHLKLRFHGRRSVMPRHPCDEIKEPLRKAILKQLGLS

Download         Length: 177 bp

Antitoxin


Download         Length: 139 a.a.        Molecular weight: 15247.61 Da        Isoelectric Point: 4.6115

>AT290171 WP_001270285.1 NZ_LR883965:c676105-675689 [Escherichia coli]
MRYPVTLTPAPEGGYMVSFVDIPEALTQGETVAEAMEAAKDALLTAFDFYFEDNELIPLPSPLNSHDHFIEVPLSVASKV
LLLNAFLQSEITQQELARRIGKPKQEITRLFDLHHATKIDAVQLAAKALGKELSLVMV

Download         Length: 417 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6HPB

Antitoxin

Source ID Structure

References