Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type V Classification (family/domain) ghoTS/ghoT-GhoS
Location 4392314..4392811 Replicon chromosome
Accession NZ_LR883050
Organism Escherichia coli isolate L1_E925

Toxin (Protein)


Gene name ghoT Uniprot ID L4JJG6
Locus tag JL017_RS21430 Protein ID WP_001173343.1
Coordinates 4392314..4392487 (-) Length 58 a.a.

Antitoxin (Protein)


Gene name ghoS Uniprot ID A0A2U9LI53
Locus tag JL017_RS21435 Protein ID WP_071597404.1
Coordinates 4392515..4392811 (-) Length 99 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JL017_RS21420 4388979..4390436 + 1458 WP_000856829.1 dipeptide/tripeptide permease DtpC -
JL017_RS21425 4390673..4392190 + 1518 WP_001295074.1 lysine--tRNA ligase -
JL017_RS21430 4392314..4392487 - 174 WP_001173343.1 type V toxin-antitoxin system toxin GhoT Toxin
JL017_RS21435 4392515..4392811 - 297 WP_071597404.1 type V toxin-antitoxin system endoribonuclease antitoxin GhoS Antitoxin
JL017_RS21440 4393038..4393310 - 273 WP_000405647.1 N-acetyltransferase -
JL017_RS21445 4393322..4393552 - 231 WP_000371704.1 (4Fe-4S)-binding protein -
JL017_RS21450 4393733..4395364 + 1632 WP_001216490.1 sensor histidine kinase -
JL017_RS21455 4395361..4396080 + 720 WP_000611288.1 two-component system response regulator DcuR -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 4351010..4392811 41801


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin GhoT/OrtT

(4-57)

Antitoxin

Endoribonuclease antitoxin GhoS

(6-94)


Sequences

Toxin        


Download         Length: 58 a.a.        Molecular weight: 6555.06 Da        Isoelectric Point: 10.2288

>T290161 WP_001173343.1 NZ_LR883050:c4392487-4392314 [Escherichia coli]
MALFSKILIFYVIGVNISFVIIWFISHEKTHIRLLSAFLVGITWPMSLPVALLFSLF

Download         Length: 174 bp

Antitoxin


Download         Length: 99 a.a.        Molecular weight: 11495.99 Da        Isoelectric Point: 4.1705

>AT290161 WP_071597404.1 NZ_LR883050:c4392811-4392515 [Escherichia coli]
MEGKNRFNTYVVSFDYPSSYSSVFLRLRSLMYDMNFSSIVADEYGIPRQLNENSFAITTSLAASEIEDLIRLKCLDLPDI
DFDLNIMTVDDYFRQFYK

Download         Length: 297 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U9QI41

Antitoxin

Source ID Structure
AlphaFold DB A0A2U9LI53

References