Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3563259..3563877 Replicon chromosome
Accession NZ_LR883050
Organism Escherichia coli isolate L1_E925

Toxin (Protein)


Gene name Hha Uniprot ID H5UYE2
Locus tag JL017_RS17335 Protein ID WP_001291435.1
Coordinates 3563659..3563877 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID -
Locus tag JL017_RS17330 Protein ID WP_000344789.1
Coordinates 3563259..3563633 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JL017_RS17320 3558348..3559541 + 1194 WP_001295324.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
JL017_RS17325 3559564..3562713 + 3150 WP_001132469.1 multidrug efflux RND transporter permease subunit -
JL017_RS17330 3563259..3563633 + 375 WP_000344789.1 Hha toxicity modulator TomB Antitoxin
JL017_RS17335 3563659..3563877 + 219 WP_001291435.1 hemolysin expression modulator Hha Toxin
JL017_RS17340 3564049..3564600 + 552 WP_000102564.1 maltose O-acetyltransferase -
JL017_RS17345 3564716..3565186 + 471 WP_000136192.1 YlaC family protein -
JL017_RS17350 3565350..3566900 + 1551 WP_001310610.1 cyclic-guanylate-specific phosphodiesterase PdeB -
JL017_RS17355 3566942..3567295 - 354 WP_000878143.1 DUF1428 domain-containing protein -
JL017_RS17365 3567674..3567985 + 312 WP_000409911.1 MGMT family protein -
JL017_RS17370 3568016..3568588 - 573 WP_000779831.1 YbaY family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-117)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T290157 WP_001291435.1 NZ_LR883050:3563659-3563877 [Escherichia coli]
MSEKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14569.44 Da        Isoelectric Point: 4.7395

>AT290157 WP_000344789.1 NZ_LR883050:3563259-3563633 [Escherichia coli]
MDEYSPKRHDIAQLKFLCEILYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINMQDLQKWRKSGNRLFRCFVNATKENPASLSC

Download         Length: 375 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 2MW2
PDB 1JW2

Antitoxin

Source ID Structure

References