Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/UPF0150(antitoxin)
Location 2538529..2539167 Replicon chromosome
Accession NZ_LR883050
Organism Escherichia coli isolate L1_E925

Toxin (Protein)


Gene name hicA Uniprot ID S1F9G9
Locus tag JL017_RS12260 Protein ID WP_000813794.1
Coordinates 2538991..2539167 (-) Length 59 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag JL017_RS12255 Protein ID WP_001270286.1
Coordinates 2538529..2538945 (-) Length 139 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JL017_RS12235 2533681..2534622 - 942 WP_001251313.1 ABC transporter permease -
JL017_RS12240 2534623..2535636 - 1014 WP_000220399.1 ABC transporter ATP-binding protein -
JL017_RS12245 2535654..2536799 - 1146 WP_000047424.1 ABC transporter substrate-binding protein -
JL017_RS12250 2537044..2538450 - 1407 WP_000760586.1 PLP-dependent aminotransferase family protein -
JL017_RS12255 2538529..2538945 - 417 WP_001270286.1 type II toxin-antitoxin system antitoxin HicB Antitoxin
JL017_RS12260 2538991..2539167 - 177 WP_000813794.1 type II toxin-antitoxin system mRNA interferase toxin HicA Toxin
JL017_RS12265 2539389..2539619 + 231 WP_000494244.1 YncJ family protein -
JL017_RS12270 2539711..2541672 - 1962 WP_001355676.1 23S rRNA 5-hydroxycytidine C2501 synthase -
JL017_RS12275 2541745..2542281 - 537 WP_000429133.1 DNA-binding transcriptional regulator SutR -
JL017_RS12280 2542334..2543548 + 1215 WP_071597387.1 BenE family transporter YdcO -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- flank IS/Tn - - 2543588..2544736 1148


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(5-57)

Antitoxin

Cro/C1-type helix-turn-helix domain

(91-134)


Sequences

Toxin        


Download         Length: 59 a.a.        Molecular weight: 6749.83 Da        Isoelectric Point: 11.2298

>T290156 WP_000813794.1 NZ_LR883050:c2539167-2538991 [Escherichia coli]
VKQSEFRRWLESQGVDVANGSNHLKLRFHGRRSVMPRHPCDEIKEPLRKAILKQLGLS

Download         Length: 177 bp

Antitoxin


Download         Length: 139 a.a.        Molecular weight: 15246.63 Da        Isoelectric Point: 4.7386

>AT290156 WP_001270286.1 NZ_LR883050:c2538945-2538529 [Escherichia coli]
MRYPVTLTPAPEGGYMVSFVDIPEALTQGETVAEAMEAAKDALLTAFDFYFEDNELIPLPSPLNSHDHFIEVPLSVASKV
LLLNAFLQSEITQQELARRIGKPKQEITRLFNLHHATKIDAVQLAAKALGKELSLVMV

Download         Length: 417 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6HPB

Antitoxin

Source ID Structure

References