Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 946625..947279 Replicon chromosome
Accession NZ_LR883050
Organism Escherichia coli isolate L1_E925

Toxin (Protein)


Gene name cptA Uniprot ID S1PAM6
Locus tag JL017_RS04650 Protein ID WP_000244781.1
Coordinates 946872..947279 (+) Length 136 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID S1PPB1
Locus tag JL017_RS04645 Protein ID WP_000354046.1
Coordinates 946625..946891 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JL017_RS04625 942713..944146 - 1434 WP_001394742.1 6-phospho-beta-glucosidase BglA -
JL017_RS04630 944191..944502 + 312 WP_001182956.1 N(4)-acetylcytidine aminohydrolase -
JL017_RS04635 944666..945325 + 660 WP_000250274.1 hemolysin III family protein -
JL017_RS04640 945402..946382 - 981 WP_000886087.1 tRNA-modifying protein YgfZ -
JL017_RS04645 946625..946891 + 267 WP_000354046.1 FAD assembly factor SdhE Antitoxin
JL017_RS04650 946872..947279 + 408 WP_000244781.1 protein YgfX Toxin
JL017_RS04655 947319..947840 - 522 WP_001055874.1 flavodoxin FldB -
JL017_RS04660 947952..948848 + 897 WP_000806650.1 site-specific tyrosine recombinase XerD -
JL017_RS04665 948873..949583 + 711 WP_000715224.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
JL017_RS04670 949589..951322 + 1734 WP_001394741.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 136 a.a.        Molecular weight: 16061.99 Da        Isoelectric Point: 11.5202

>T290149 WP_000244781.1 NZ_LR883050:946872-947279 [Escherichia coli]
VVLWQSDLRVSWRAQWLSLLIHGLVAAVILLMPWPLSYTPLWMVLLSLVVFDCVRSQRRINARQGEIRLLMDGRLRWQGQ
EWSIVKAPWMIKSGMMLRLRSDSGKRQHLWLAADSMDEAEWRDLRRILLQQETQR

Download         Length: 408 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10547.12 Da        Isoelectric Point: 5.1599

>AT290149 WP_000354046.1 NZ_LR883050:946625-946891 [Escherichia coli]
MDINNKARIHWACRRGMRELDISIMPFFEHEYDSLSDDEKRIFIRLLECDDPDLFNWLMNHGKPADAELEMMVRLIQTRN
RERGPVAI

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB S1PAM6

Antitoxin

Source ID Structure
PDB 6B58
PDB 1X6I
PDB 1X6J
PDB 6C12
AlphaFold DB A0A7U9QD57

References