Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3562204..3562822 Replicon chromosome
Accession NZ_LR883012
Organism Escherichia coli isolate L4_E1441_ETEC

Toxin (Protein)


Gene name Hha Uniprot ID H5UYE2
Locus tag JLZ95_RS17270 Protein ID WP_001291435.1
Coordinates 3562604..3562822 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID S1PTH5
Locus tag JLZ95_RS17265 Protein ID WP_000344800.1
Coordinates 3562204..3562578 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JLZ95_RS17255 3557293..3558486 + 1194 WP_001295324.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
JLZ95_RS17260 3558509..3561658 + 3150 WP_001132469.1 multidrug efflux RND transporter permease subunit -
JLZ95_RS17265 3562204..3562578 + 375 WP_000344800.1 Hha toxicity modulator TomB Antitoxin
JLZ95_RS17270 3562604..3562822 + 219 WP_001291435.1 hemolysin expression modulator Hha Toxin
JLZ95_RS17275 3562994..3563545 + 552 WP_001727569.1 maltose O-acetyltransferase -
JLZ95_RS17280 3563661..3564131 + 471 WP_000136192.1 YlaC family protein -
JLZ95_RS17285 3564295..3565845 + 1551 WP_001727568.1 cyclic-guanylate-specific phosphodiesterase PdeB -
JLZ95_RS17290 3565887..3566240 - 354 WP_000878140.1 DUF1428 domain-containing protein -
JLZ95_RS17300 3566619..3566930 + 312 WP_000409911.1 MGMT family protein -
JLZ95_RS17305 3566961..3567533 - 573 WP_000779831.1 YbaY family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-117)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T290133 WP_001291435.1 NZ_LR883012:3562604-3562822 [Escherichia coli]
MSEKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14557.39 Da        Isoelectric Point: 4.7395

>AT290133 WP_000344800.1 NZ_LR883012:3562204-3562578 [Escherichia coli]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINMQDLQKWRKSGNRLFRCFVNATKENPASLSC

Download         Length: 375 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 2MW2
PDB 1JW2

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9QBQ5

References