Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 938283..938937 Replicon chromosome
Accession NZ_LR883012
Organism Escherichia coli isolate L4_E1441_ETEC

Toxin (Protein)


Gene name cptA Uniprot ID S1PAM6
Locus tag JLZ95_RS04520 Protein ID WP_000244781.1
Coordinates 938530..938937 (+) Length 136 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID S1PPB1
Locus tag JLZ95_RS04515 Protein ID WP_000354046.1
Coordinates 938283..938549 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JLZ95_RS04495 934371..935804 - 1434 WP_001394742.1 6-phospho-beta-glucosidase BglA -
JLZ95_RS04500 935849..936160 + 312 WP_001182956.1 N(4)-acetylcytidine aminohydrolase -
JLZ95_RS04505 936324..936983 + 660 WP_000250274.1 hemolysin III family protein -
JLZ95_RS04510 937060..938040 - 981 WP_000886087.1 tRNA-modifying protein YgfZ -
JLZ95_RS04515 938283..938549 + 267 WP_000354046.1 FAD assembly factor SdhE Antitoxin
JLZ95_RS04520 938530..938937 + 408 WP_000244781.1 protein YgfX Toxin
JLZ95_RS04525 938977..939498 - 522 WP_001055874.1 flavodoxin FldB -
JLZ95_RS04530 939610..940506 + 897 WP_001735667.1 site-specific tyrosine recombinase XerD -
JLZ95_RS04535 940531..941241 + 711 WP_000715222.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
JLZ95_RS04540 941247..942980 + 1734 WP_000813233.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 136 a.a.        Molecular weight: 16061.99 Da        Isoelectric Point: 11.5202

>T290124 WP_000244781.1 NZ_LR883012:938530-938937 [Escherichia coli]
VVLWQSDLRVSWRAQWLSLLIHGLVAAVILLMPWPLSYTPLWMVLLSLVVFDCVRSQRRINARQGEIRLLMDGRLRWQGQ
EWSIVKAPWMIKSGMMLRLRSDSGKRQHLWLAADSMDEAEWRDLRRILLQQETQR

Download         Length: 408 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10547.12 Da        Isoelectric Point: 5.1599

>AT290124 WP_000354046.1 NZ_LR883012:938283-938549 [Escherichia coli]
MDINNKARIHWACRRGMRELDISIMPFFEHEYDSLSDDEKRIFIRLLECDDPDLFNWLMNHGKPADAELEMMVRLIQTRN
RERGPVAI

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB S1PAM6

Antitoxin

Source ID Structure
PDB 6B58
PDB 1X6I
PDB 1X6J
PDB 6C12
AlphaFold DB A0A7U9QD57

References