Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 843918..844750 Replicon chromosome
Accession NZ_LR883012
Organism Escherichia coli isolate L4_E1441_ETEC

Toxin (Protein)


Gene name yeeV Uniprot ID A7ZVJ9
Locus tag JLZ95_RS04025 Protein ID WP_000854765.1
Coordinates 843918..844292 (-) Length 125 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID S1NM52
Locus tag JLZ95_RS04030 Protein ID WP_001295723.1
Coordinates 844382..844750 (-) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JLZ95_RS04005 841710..842930 + 1221 WP_001735713.1 capsular biosynthesis protein -
JLZ95_RS04010 842953..843189 - 237 WP_001735712.1 hypothetical protein -
JLZ95_RS04015 843292..843468 - 177 WP_000839288.1 DUF957 domain-containing protein -
JLZ95_RS04020 843485..843921 - 437 Protein_790 hypothetical protein -
JLZ95_RS04025 843918..844292 - 375 WP_000854765.1 TA system toxin CbtA family protein Toxin
JLZ95_RS04030 844382..844750 - 369 WP_001295723.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
JLZ95_RS04035 844913..845134 - 222 WP_001735710.1 DUF987 domain-containing protein -
JLZ95_RS04040 845203..845679 - 477 WP_001186725.1 RadC family protein -
JLZ95_RS04045 845695..846180 - 486 WP_001735709.1 antirestriction protein -
JLZ95_RS04050 846235..847053 - 819 WP_074481115.1 DUF945 domain-containing protein -
JLZ95_RS04055 847208..847366 - 159 WP_001323397.1 DUF905 family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(18-117)


Sequences

Toxin        


Download         Length: 125 a.a.        Molecular weight: 13970.98 Da        Isoelectric Point: 7.2909

>T290123 WP_000854765.1 NZ_LR883012:c844292-843918 [Escherichia coli]
MKTLPDTHVREVSCCPSPVTIWQTLLTRLLDQHYSLTLNDTPFVDERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SAGASSQLINSIDILRARRATGLMTRHNYRTVNNITLGKYPEAK

Download         Length: 375 bp

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13592.40 Da        Isoelectric Point: 6.6255

>AT290123 WP_001295723.1 NZ_LR883012:c844750-844382 [Escherichia coli]
VSDTLSGTTHPDDNDDHPWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGRFRDADAYPLDQAFPLLMKQLKLMLTSG
ELNPRHQHTVTLYAKGLTCEADTLGSCGYVYLAVYPTPETKK

Download         Length: 369 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A7ZVJ9

Antitoxin

Source ID Structure
AlphaFold DB S1NM52

References