Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-YafN
Location 1813..2348 Replicon plasmid 3
Accession NZ_LR883008
Organism Escherichia coli isolate L5_E1779_ETEC

Toxin (Protein)


Gene name relE Uniprot ID T2HS21
Locus tag JL014_RS24520 Protein ID WP_000222775.1
Coordinates 2061..2348 (+) Length 96 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID T2HSA2
Locus tag JL014_RS24515 Protein ID WP_001139207.1
Coordinates 1813..2064 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JL014_RS24505 1..858 + 858 WP_000130987.1 incFII family plasmid replication initiator RepA -
JL014_RS24510 1559..1726 + 168 WP_000841011.1 hypothetical protein -
JL014_RS24515 1813..2064 + 252 WP_001139207.1 plasmid stabilization protein Antitoxin
JL014_RS24520 2061..2348 + 288 WP_000222775.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
JL014_RS24525 2358..2903 + 546 WP_000926983.1 hypothetical protein -
JL014_RS24530 3555..4157 - 603 WP_000517689.1 hypothetical protein -
JL014_RS24535 4511..4759 + 249 Protein_7 hypothetical protein -
JL014_RS24540 4798..5943 - 1146 Protein_8 IS66 family transposase -
JL014_RS24545 5997..6674 + 678 WP_001711999.1 IS66 family insertion sequence hypothetical protein -
JL014_RS24550 6674..7021 + 348 WP_000624622.1 IS66 family insertion sequence element accessory protein TnpB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Mobilizable plasmid - cssA / csfA 1..142377 142377


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-86)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 11142.17 Da        Isoelectric Point: 10.6261

>T290117 WP_000222775.1 NZ_LR883008:2061-2348 [Escherichia coli]
MTYTVKFRDDALREWLKLDKSVQQQFAKKLKKCSENPHIPSAKLRGLKDCYKIKLRASGFRLVYQVIDDMLIIAVVAVGK
RERSHVYNLASERMR

Download         Length: 288 bp

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9216.45 Da        Isoelectric Point: 4.0927

>AT290117 WP_001139207.1 NZ_LR883008:1813-2064 [Escherichia coli]
MPSIILSDTSASVSELKKNPMATVSAGEGYPVAILNRNQPAFYCVPAELYERMLDAMDDQELVKLVTERSNQPLHDVDLD
SYL

Download         Length: 252 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB T2HS21

Antitoxin

Source ID Structure
AlphaFold DB A0A754EQ65

References