Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) chpSB/PRK09812-ChpS
Location 4271170..4271765 Replicon chromosome
Accession NZ_LR883006
Organism Escherichia coli isolate L5_E1779_ETEC

Toxin (Protein)


Gene name chpB Uniprot ID U9Y4M4
Locus tag JL014_RS20800 Protein ID WP_000239579.1
Coordinates 4271415..4271765 (+) Length 117 a.a.

Antitoxin (Protein)


Gene name chpS Uniprot ID U9Y2K1
Locus tag JL014_RS20795 Protein ID WP_001223208.1
Coordinates 4271170..4271421 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JL014_RS20785 4266835..4270614 + 3780 WP_000060896.1 autotransporter assembly complex protein TamB -
JL014_RS20790 4270617..4270958 + 342 WP_001219160.1 gamma-glutamylcyclotransferase -
JL014_RS20795 4271170..4271421 + 252 WP_001223208.1 type II toxin-antitoxin system antitoxin ChpS Antitoxin
JL014_RS20800 4271415..4271765 + 351 WP_000239579.1 endoribonuclease toxin ChpB Toxin
JL014_RS20805 4271845..4272375 - 531 WP_000055075.1 inorganic diphosphatase -
JL014_RS20810 4272685..4273641 + 957 WP_000265933.1 galactofuranose ABC transporter substrate-binding protein YtfQ -
JL014_RS20815 4273951..4275453 + 1503 WP_000205791.1 sugar ABC transporter ATP-binding protein -
JL014_RS20820 4275467..4276489 + 1023 WP_001355798.1 ABC transporter permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(8-114)

Antitoxin

SpoVT-AbrB domain

(6-49)


Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 12511.45 Da        Isoelectric Point: 5.6219

>T290114 WP_000239579.1 NZ_LR883006:4271415-4271765 [Escherichia coli]
MVKKSEFERGDIVLVGFDPASGHEQQGAGRPALVLSVQAFNQLGMTLVAPITQGGNFARYAGFSVPLHCEEGDVHGVVLV
NQVRMMDLRARLAKRIGLAADEVVEEALLRLQAVVE

Download         Length: 351 bp

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9271.58 Da        Isoelectric Point: 4.4201

>AT290114 WP_001223208.1 NZ_LR883006:4271170-4271421 [Escherichia coli]
MRITIKRWGNSAGMVIPNIVMKELNLQPGQSVEAQVSNNQLILTPISRRYSLDELLAQCDMNAAELSEQDVWGKSTPAGD
EIW

Download         Length: 252 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0Y8A8

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9LQ26

References