Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3647357..3647975 Replicon chromosome
Accession NZ_LR883006
Organism Escherichia coli isolate L5_E1779_ETEC

Toxin (Protein)


Gene name Hha Uniprot ID H5UYE2
Locus tag JL014_RS17855 Protein ID WP_001291435.1
Coordinates 3647757..3647975 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID S1PTH5
Locus tag JL014_RS17850 Protein ID WP_000344800.1
Coordinates 3647357..3647731 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JL014_RS17840 3642446..3643639 + 1194 WP_001295324.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
JL014_RS17845 3643662..3646811 + 3150 WP_001132469.1 multidrug efflux RND transporter permease subunit -
JL014_RS17850 3647357..3647731 + 375 WP_000344800.1 Hha toxicity modulator TomB Antitoxin
JL014_RS17855 3647757..3647975 + 219 WP_001291435.1 hemolysin expression modulator Hha Toxin
JL014_RS17860 3648147..3648698 + 552 WP_000102568.1 maltose O-acetyltransferase -
JL014_RS17865 3648814..3649284 + 471 WP_000136192.1 YlaC family protein -
JL014_RS17870 3649448..3650998 + 1551 WP_001299455.1 cyclic-guanylate-specific phosphodiesterase PdeB -
JL014_RS17875 3651040..3651393 - 354 WP_000878140.1 DUF1428 domain-containing protein -
JL014_RS17885 3651772..3652083 + 312 WP_000409911.1 MGMT family protein -
JL014_RS17890 3652114..3652686 - 573 WP_000779831.1 YbaY family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-117)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T290108 WP_001291435.1 NZ_LR883006:3647757-3647975 [Escherichia coli]
MSEKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14557.39 Da        Isoelectric Point: 4.7395

>AT290108 WP_000344800.1 NZ_LR883006:3647357-3647731 [Escherichia coli]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINMQDLQKWRKSGNRLFRCFVNATKENPASLSC

Download         Length: 375 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 2MW2
PDB 1JW2

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9QBQ5

References