Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 1391979..1392604 Replicon chromosome
Accession NZ_LR883006
Organism Escherichia coli isolate L5_E1779_ETEC

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag JL014_RS06775 Protein ID WP_000911328.1
Coordinates 1392206..1392604 (+) Length 133 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID U9XQV3
Locus tag JL014_RS06770 Protein ID WP_000450524.1
Coordinates 1391979..1392206 (+) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JL014_RS06745 1387782..1388252 - 471 WP_001068682.1 thioredoxin-dependent thiol peroxidase -
JL014_RS06750 1388252..1388824 - 573 WP_000176187.1 glycine cleavage system transcriptional repressor -
JL014_RS06755 1388970..1389848 + 879 WP_001295469.1 4-hydroxy-tetrahydrodipicolinate synthase -
JL014_RS06760 1389865..1390899 + 1035 WP_001297320.1 outer membrane protein assembly factor BamC -
JL014_RS06765 1391112..1391825 + 714 WP_001295467.1 phosphoribosylaminoimidazolesuccinocarboxamide synthase -
JL014_RS06770 1391979..1392206 + 228 WP_000450524.1 toxin-antitoxin system antitoxin VapB Antitoxin
JL014_RS06775 1392206..1392604 + 399 WP_000911328.1 tRNA(fMet)-specific endonuclease VapC Toxin
JL014_RS06780 1392751..1393614 + 864 WP_001267508.1 neutral zinc metallopeptidase -
JL014_RS06785 1393629..1395644 + 2016 WP_000829355.1 tRNA cytosine(34) acetyltransferase TmcA -
JL014_RS06790 1395718..1396416 + 699 WP_000679823.1 esterase -
JL014_RS06795 1396526..1396726 - 201 WP_000383836.1 YpfN family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-125)

Antitoxin

SpoVT-AbrB domain

(7-52)


Sequences

Toxin        


Download         Length: 133 a.a.        Molecular weight: 14966.32 Da        Isoelectric Point: 8.5325

>T290097 WP_000911328.1 NZ_LR883006:1392206-1392604 [Escherichia coli]
MLKFMLDTNICIFTIKNKPVHVRERFNLNSGRMCISSVTLMELIYEAEKSQMPERNLAVIEGFVSRLVVLDYDSAAATHT
GQIRAELARQGRPVGPFDQMIAGHARSRGLIVVTNNTREFERVAGIRLEDWS

Download         Length: 399 bp

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8498.61 Da        Isoelectric Point: 4.3867

>AT290097 WP_000450524.1 NZ_LR883006:1391979-1392206 [Escherichia coli]
METTVFLSNRSQAVRLPKAVALPEDVKKVEIIAIGRTRIITPAGESWDSWFDGENVSADFMDIRDQPAMQERESF

Download         Length: 228 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A829CM33

References