Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RHH(antitoxin)
Location 1778..2337 Replicon plasmid 3
Accession NZ_LR882999
Organism Escherichia coli isolate L3_E36_ETEC

Toxin (Protein)


Gene name relE Uniprot ID S1PMX5
Locus tag JL022_RS27360 Protein ID WP_000421257.1
Coordinates 2062..2337 (+) Length 92 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID U9Y625
Locus tag JL022_RS27355 Protein ID WP_001178087.1
Coordinates 1778..2062 (+) Length 95 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JL022_RS27350 1..873 + 873 WP_000729438.1 incFII family plasmid replication initiator RepA -
JL022_RS27355 1778..2062 + 285 WP_001178087.1 ribbon-helix-helix domain-containing protein Antitoxin
JL022_RS27360 2062..2337 + 276 WP_000421257.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
JL022_RS27365 2594..3802 - 1209 WP_001695118.1 IS91 family transposase -
JL022_RS27370 3783..4055 - 273 WP_001695087.1 hypothetical protein -
JL022_RS27375 4183..5391 + 1209 WP_001352368.1 IS4-like element ISVsa5 family transposase -
JL022_RS27380 5407..5526 - 120 Protein_6 LysR family transcriptional regulator -
JL022_RS27385 5757..6962 - 1206 WP_000599533.1 sodium/glutamate symporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Conjugative plasmid tet(B) - 1..99448 99448


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(3-90)

Antitoxin

Ribbon-helix-helix protein, CopG

(14-51)


Sequences

Toxin        


Download         Length: 92 a.a.        Molecular weight: 10749.45 Da        Isoelectric Point: 9.9324

>T290091 WP_000421257.1 NZ_LR882999:2062-2337 [Escherichia coli]
MELKWTSKALSDLARLYDFLVLASKPAAARTVQSLTQAPVILLTHPRMGEQLFQFEPREVRRIFAGEYEIRYELNGQTIY
VLRLWHTRENR

Download         Length: 276 bp

Antitoxin


Download         Length: 95 a.a.        Molecular weight: 10488.92 Da        Isoelectric Point: 5.6558

>AT290091 WP_001178087.1 NZ_LR882999:1778-2062 [Escherichia coli]
MQMKNNTAQATKVITAHVPLPMADKVDQMAARLERSRGWIIKQALSAWLAQEEERNRLTLEALDDVTSGQVIDHQAVQAW
ADSLSTDNPLPVPR

Download         Length: 285 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB S1PMX5

Antitoxin

Source ID Structure
AlphaFold DB U9Y625

References