Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RHH(antitoxin)
Location 207531..208090 Replicon plasmid 2
Accession NZ_LR882998
Organism Escherichia coli isolate L3_E36_ETEC

Toxin (Protein)


Gene name relE Uniprot ID E3PPG0
Locus tag JL022_RS26355 Protein ID WP_000421265.1
Coordinates 207531..207806 (-) Length 92 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID E3PPG1
Locus tag JL022_RS26360 Protein ID WP_001743519.1
Coordinates 207806..208090 (-) Length 95 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JL022_RS26335 202786..203211 + 426 Protein_261 IS3 family transposase -
JL022_RS26340 203884..205392 + 1509 WP_001189123.1 group II intron reverse transcriptase/maturase -
JL022_RS26345 205473..205940 + 468 Protein_263 IS3 family transposase -
JL022_RS26350 206292..207368 - 1077 WP_000610005.1 hypothetical protein -
JL022_RS26355 207531..207806 - 276 WP_000421265.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
JL022_RS26360 207806..208090 - 285 WP_001743519.1 ribbon-helix-helix domain-containing protein Antitoxin
JL022_RS26365 208844..210563 - 1720 Protein_267 ATP-binding protein -
JL022_RS26370 210556..211253 - 698 Protein_268 IS1 family transposase -
JL022_RS26375 211702..211899 - 198 WP_001381161.1 hypothetical protein -
JL022_RS26380 212112..212678 - 567 WP_000904908.1 recombinase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Conjugative plasmid - eltB / eltA / cofA / etpA / etpB / cfaA / cfaB / cfaC / cfaE / cfaD' 1..381858 381858
- inside IScluster/Tn - - 201300..215857 14557


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(3-90)

Antitoxin

Ribbon-helix-helix protein, CopG

(14-51)


Sequences

Toxin        


Download         Length: 92 a.a.        Molecular weight: 10742.45 Da        Isoelectric Point: 9.9324

>T290085 WP_000421265.1 NZ_LR882998:c207806-207531 [Escherichia coli]
MELKWTSKALSDLARLYDFLVLASKPAAARTVQSLTQASVILLTHPRMGEQLFQFELREVRRIFAGEYEIRYELTGQTIY
VLRLWHTRENR

Download         Length: 276 bp

Antitoxin


Download         Length: 95 a.a.        Molecular weight: 10490.95 Da        Isoelectric Point: 5.6546

>AT290085 WP_001743519.1 NZ_LR882998:c208090-207806 [Escherichia coli]
MQMKNNCAQATKVITAHVPLPMADKVDQMAARLERSRGWVIKQALSAWLAQEEERNRLTLEALDDVTSGQIIDHQAVQAW
ADSLSTDNPLPVPR

Download         Length: 285 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB E3PPG0

Antitoxin

Source ID Structure
AlphaFold DB E3PPG1

References