Detailed information of TA system TA290075

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): mosAT/AbiEii-AbiEi
• Location: 4492750..4494433
• Replicon: chromosome
• Accession: NZ_LR882997
• Organism: Escherichia coli isolate L3_E36_ETEC

Toxin (Protein)

• Gene name: mosT
• Uniprot ID: -
• Locus tag: JL022_RS21935
• Protein ID: WP_000361918.1
• Coordinates: 4493516..4494433 (+)
• Length: 306 a.a.

Antitoxin (Protein)

• Gene name: mosA
• Uniprot ID: -
• Locus tag: JL022_RS21930
• Protein ID: WP_001695295.1
• Coordinates: 4492750..4493523 (+)
• Length: 258 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
JL022_RS21915	4488618..4490702	+	2085	WP_001193075.1	protease Lon-related BREX system protein BrxL	-
JL022_RS21920	4490821..4492170	+	1350	WP_001695296.1	PLD-like domain protein	-
JL022_RS21925	4492346..4492666	-	321	Protein_4292	IS3 family transposase	-
JL022_RS21930	4492750..4493523	+	774	WP_001695295.1	type IV toxin-antitoxin system AbiEi family antitoxin	Antitoxin
JL022_RS21935	4493516..4494433	+	918	WP_000361918.1	nucleotidyl transferase AbiEii/AbiGii toxin family protein	Toxin
JL022_RS21940	4494727..4494894	+	168	WP_001356018.1	hypothetical protein	-
JL022_RS21945	4494947..4495609	-	663	WP_096955309.1	hypothetical protein	-
JL022_RS21950	4495613..4496323	-	711	WP_001219054.1	integrase arm-type DNA-binding domain-containing protein	-
JL022_RS21955	4497083..4499416	-	2334	WP_099486200.1	toprim domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Nucleotidyl transferase AbiEii toxin, Type IV TA system (13-278)

Antitoxin

• Transcriptional regulator AbiEi antitoxin, N-terminal domain (1-93)

Sequences

Toxin

Protein

• Length: 306 a.a.
• Molecular weight: 34962.10 Da
• Isoelectric Point: 4.9206

>T290075 WP_000361918.1 NZ_LR882997:4493516-4494433 [Escherichia coli]
MDKTSPYYRQVALLVRALPWVANESCFALKGGTAINLFIHDFPRLSVDIDLAWIPLESREVALPNVREALTRIAAELKAQ
TGIRAVLQTHNPDEMRIIVTTDDAQIKIEVSPVARGTLYPPQERDIVGAVEEEFGFAALPVVSLPDLYGGKLCAALDRQH
PRDFYDVKMLLDTQGIDRSIFNGFIVYLLSHNRPLSEVLNPRWKDITEPFQNEFSGMTFEEVSLEELKEVPERMLSTLKT
HFTQQDFDFLMSFKRGEPDWNLAPEPHIQNLPAVQWKLRNIGQMSEEKRAQSLEKLEKVMTEWLR

Nucleotide

• Length: 918 bp

Antitoxin

Protein

• Length: 258 a.a.
• Molecular weight: 29347.83 Da
• Isoelectric Point: 10.0713

>AT290075 WP_001695295.1 NZ_LR882997:4492750-4493523 [Escherichia coli]
MASKLNWLLQNTSPGSLVLQSWLTRNNISPSLAFKYAQNGWLIKLRAGVYARAGREPDWSDALWCLQNQLEAPVHLAGLS
SLSWQGRSHYLQLKQNQCWLSVENKAILPKWFKEFPAVEWLMVSALKLPDLDEKYRTELEVKGKRITASTPELAAYELLS
AVPQEISFEHAAELFQGLVNLKPRKVEKLLTLSQSVQTKRLYLFFASFYEHAWFKRIDTSKINLGSGNRQIVVNGKLNTQ
YQITVPENFTKKGISHG

Nucleotide

• Length: 774 bp