Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 1996474..1997306 Replicon chromosome
Accession NZ_LR882997
Organism Escherichia coli isolate L3_E36_ETEC

Toxin (Protein)


Gene name yeeV Uniprot ID -
Locus tag JL022_RS09685 Protein ID WP_000854762.1
Coordinates 1996474..1996848 (-) Length 125 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID S1NM52
Locus tag JL022_RS09690 Protein ID WP_001295723.1
Coordinates 1996938..1997306 (-) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JL022_RS09660 1991690..1993198 - 1509 WP_001189123.1 group II intron reverse transcriptase/maturase -
JL022_RS09665 1993871..1994610 - 740 Protein_1893 IS3 family transposase -
JL022_RS09670 1994660..1996024 + 1365 Protein_1894 IS66-like element ISEc23 family transposase -
JL022_RS09675 1996145..1996258 - 114 WP_001161660.1 DUF957 domain-containing protein -
JL022_RS09680 1996271..1996477 - 207 WP_000976829.1 hypothetical protein -
JL022_RS09685 1996474..1996848 - 375 WP_000854762.1 TA system toxin CbtA family protein Toxin
JL022_RS09690 1996938..1997306 - 369 WP_001295723.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
JL022_RS09695 1997469..1997690 - 222 WP_000692341.1 DUF987 domain-containing protein -
JL022_RS09700 1997753..1998229 - 477 WP_001186774.1 RadC family protein -
JL022_RS09705 1998245..1998718 - 474 WP_000855059.1 antirestriction protein -
JL022_RS09710 1999060..1999878 - 819 WP_001234652.1 DUF945 domain-containing protein -
JL022_RS09715 2000033..2000191 - 159 WP_001433433.1 DUF905 family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 1985710..2003108 17398


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(18-117)


Sequences

Toxin        


Download         Length: 125 a.a.        Molecular weight: 14094.15 Da        Isoelectric Point: 7.1881

>T290065 WP_000854762.1 NZ_LR882997:c1996848-1996474 [Escherichia coli]
MKTLPDTHVREVSCCPSPVTIWQTLLTRLLDQHYSLTLNDTPFVDERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SACTRSQLINSIDILRARRATGLMTRDNYRTVNNITLGKYPEAK

Download         Length: 375 bp

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13592.40 Da        Isoelectric Point: 6.6255

>AT290065 WP_001295723.1 NZ_LR882997:c1997306-1996938 [Escherichia coli]
VSDTLSGTTHPDDNDDHPWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGRFRDADAYPLDQAFPLLMKQLKLMLTSG
ELNPRHQHTVTLYAKGLTCEADTLGSCGYVYLAVYPTPETKK

Download         Length: 369 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB S1NM52

References