Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 1476138..1476763 Replicon chromosome
Accession NZ_LR882997
Organism Escherichia coli isolate L3_E36_ETEC

Toxin (Protein)


Gene name vapC Uniprot ID U9YZ02
Locus tag JL022_RS07285 Protein ID WP_000911329.1
Coordinates 1476365..1476763 (+) Length 133 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag JL022_RS07280 Protein ID WP_001696518.1
Coordinates 1476138..1476365 (+) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JL022_RS07255 1471940..1472410 - 471 WP_001068682.1 thioredoxin-dependent thiol peroxidase -
JL022_RS07260 1472410..1472982 - 573 WP_000176187.1 glycine cleavage system transcriptional repressor -
JL022_RS07265 1473128..1474006 + 879 WP_001295469.1 4-hydroxy-tetrahydrodipicolinate synthase -
JL022_RS07270 1474023..1475057 + 1035 WP_001297320.1 outer membrane protein assembly factor BamC -
JL022_RS07275 1475270..1475983 + 714 WP_200995751.1 phosphoribosylaminoimidazolesuccinocarboxamide synthase -
JL022_RS07280 1476138..1476365 + 228 WP_001696518.1 toxin-antitoxin system antitoxin VapB Antitoxin
JL022_RS07285 1476365..1476763 + 399 WP_000911329.1 tRNA(fMet)-specific endonuclease VapC Toxin
JL022_RS07290 1476910..1477773 + 864 WP_001267498.1 neutral zinc metallopeptidase -
JL022_RS07295 1477788..1479803 + 2016 WP_001388162.1 tRNA cytosine(34) acetyltransferase TmcA -
JL022_RS07300 1479877..1480575 + 699 WP_000679812.1 esterase -
JL022_RS07305 1480656..1480856 - 201 WP_000383836.1 YpfN family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element - algU 1333982..1504928 170946


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-125)

Antitoxin

SpoVT-AbrB domain

(7-51)


Sequences

Toxin        


Download         Length: 133 a.a.        Molecular weight: 14924.23 Da        Isoelectric Point: 8.5325

>T290063 WP_000911329.1 NZ_LR882997:1476365-1476763 [Escherichia coli]
MLKFMLDTNICIFTIKNKPVHVRERFNLNSGRMCISSVTLMELIYGAEKSQMPERNLAVIEGFVSRLEVLDYDSAAATHT
GQIRAELARQGRPVGPFDQMIAGHARSRGLIVVTNNTREFERVAGIRLEDWS

Download         Length: 399 bp

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8526.66 Da        Isoelectric Point: 4.3867

>AT290063 WP_001696518.1 NZ_LR882997:1476138-1476365 [Escherichia coli]
METTVFLSNRSQAVRLPKAVALPEDVKKVEIIVIGRTRIITPAGESWDSWFDGENVSADFMDIRDQPAMQERESF

Download         Length: 228 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0XW84

Antitoxin

Source ID Structure

References