Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/-
Location 313153..313784 Replicon chromosome
Accession NZ_LR882997
Organism Escherichia coli isolate L3_E36_ETEC

Toxin (Protein)


Gene name hicA Uniprot ID U9Y2A7
Locus tag JL022_RS01405 Protein ID WP_001259385.1
Coordinates 313153..313428 (+) Length 92 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID Q31VE4
Locus tag JL022_RS01410 Protein ID WP_000593554.1
Coordinates 313425..313784 (+) Length 120 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JL022_RS01390 308157..309224 + 1068 WP_000361467.1 HlyD family secretion protein -
JL022_RS01395 309221..311956 + 2736 WP_000149165.1 ribosome-associated ATPase/putative transporter RbbA -
JL022_RS01400 311956..313080 + 1125 WP_001314210.1 ABC transporter permease -
JL022_RS01405 313153..313428 + 276 WP_001259385.1 type II toxin-antitoxin system HicA family toxin Toxin
JL022_RS01410 313425..313784 + 360 WP_000593554.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
JL022_RS01415 313834..314694 - 861 WP_001131783.1 class II aldolase -
JL022_RS01420 314726..314995 - 270 WP_000933060.1 HPr family phosphocarrier protein -
JL022_RS01425 314985..316493 - 1509 WP_001298718.1 carbohydrate kinase -
JL022_RS01430 316486..317844 - 1359 WP_001298729.1 PTS galactitol transporter subunit IIC -
JL022_RS01435 317921..318202 - 282 WP_000084022.1 PTS sugar transporter subunit IIB -
JL022_RS01440 318199..318672 - 474 WP_001161553.1 PTS sugar transporter subunit IIA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 298091..320043 21952


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(30-80)

Antitoxin

Uncharacterised protein family HicB

(60-112)


Sequences

Toxin        


Download         Length: 92 a.a.        Molecular weight: 10199.94 Da        Isoelectric Point: 10.7076

>T290059 WP_001259385.1 NZ_LR882997:313153-313428 [Escherichia coli]
MRTKVQALRKKQKNTLDQIFKTPVPQGIKWSDIESLVKALGGEIKEGRGSRCKFILNMSVACFHRPHPSPDTDKGAVESV
RDWLLSIGVKP

Download         Length: 276 bp

Antitoxin


Download         Length: 120 a.a.        Molecular weight: 13359.25 Da        Isoelectric Point: 4.8838

>AT290059 WP_000593554.1 NZ_LR882997:313425-313784 [Escherichia coli]
MIKLKTPNSMEIAGQPAVITYVPELNAFRGKFLGLSGYCDFVSDSIQGLQKEGELSLLEYLEDCKAAGIEPYARTEKIKT
FTLRYPESLSERLNNAAAQQQVSVNTYIIETLNERLNHL

Download         Length: 360 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A4P7TTW8

Antitoxin

Source ID Structure
AlphaFold DB A0A6H2GM94

References