Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-YafN
Location 124198..124772 Replicon plasmid 2
Accession NZ_LR882991
Organism Escherichia coli isolate L7_E1373_ETEC

Toxin (Protein)


Gene name relE Uniprot ID A0A0S3PMZ8
Locus tag JLZ97_RS24230 Protein ID WP_001595119.1
Coordinates 124198..124524 (-) Length 109 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A0S3PN98
Locus tag JLZ97_RS24235 Protein ID WP_001595120.1
Coordinates 124521..124772 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JLZ97_RS24210 119421..121856 + 2436 WP_157757767.1 CS6 fimbrial usher CssD -
JLZ97_RS24215 121870..122432 - 563 Protein_148 IS1 family transposase -
JLZ97_RS24220 122621..123798 - 1178 Protein_149 IS91 family transposase -
JLZ97_RS24225 123798..124094 - 297 WP_000766063.1 hypothetical protein -
JLZ97_RS24230 124198..124524 - 327 WP_001595119.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
JLZ97_RS24235 124521..124772 - 252 WP_001595120.1 hypothetical protein Antitoxin
JLZ97_RS24240 125326..126192 + 867 WP_001595122.1 AAA family ATPase -
JLZ97_RS24245 126192..127223 + 1032 WP_001595123.1 ParB/RepB/Spo0J family partition protein -
JLZ97_RS24250 127247..127660 + 414 WP_032159708.1 hypothetical protein -
JLZ97_RS24255 127657..127980 + 324 WP_000143877.1 hypothetical protein -
JLZ97_RS24260 128019..129293 - 1275 WP_001595125.1 Y-family DNA polymerase -
JLZ97_RS24265 129293..129715 - 423 WP_001595126.1 translesion error-prone DNA polymerase V autoproteolytic subunit -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - cofA / faeD / faeE / estIa / cssA 1..146433 146433


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-83)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 109 a.a.        Molecular weight: 12187.44 Da        Isoelectric Point: 10.4373

>T290058 WP_001595119.1 NZ_LR882991:c124524-124198 [Escherichia coli]
MTYTVKFRDDALKEWLKLDKAIQQQFAKKLKKCSENPHIPSAKLRGIKDCYKIKLRASGFRLVYQVIDDQLIIAVVAIGK
RERSDVYNLASRVGSLAAAACHGLKLPL

Download         Length: 327 bp

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9144.43 Da        Isoelectric Point: 4.2975

>AT290058 WP_001595120.1 NZ_LR882991:c124772-124521 [Escherichia coli]
MPNIILTDTSASVSELKKNPMATVSAGDGYPVAILNRNQPAFYCVPAELYGKMLDAMDDQELVKLVAERSNQKLHDVDLD
SYL

Download         Length: 252 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0S3PMZ8

Antitoxin

Source ID Structure
AlphaFold DB A0A0S3PN98

References