Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/UPF0150(antitoxin)
Location 2510117..2510755 Replicon chromosome
Accession NZ_LR882990
Organism Escherichia coli isolate L7_E1373_ETEC

Toxin (Protein)


Gene name hicA Uniprot ID A0A3T4J978
Locus tag JLZ97_RS11920 Protein ID WP_001612987.1
Coordinates 2510579..2510755 (-) Length 59 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag JLZ97_RS11915 Protein ID WP_001270286.1
Coordinates 2510117..2510533 (-) Length 139 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JLZ97_RS11895 2505269..2506210 - 942 WP_001251315.1 ABC transporter permease -
JLZ97_RS11900 2506211..2507224 - 1014 WP_000220411.1 ABC transporter ATP-binding protein -
JLZ97_RS11905 2507242..2508387 - 1146 WP_001612991.1 ABC transporter substrate-binding protein -
JLZ97_RS11910 2508632..2510038 - 1407 WP_001718258.1 PLP-dependent aminotransferase family protein -
JLZ97_RS11915 2510117..2510533 - 417 WP_001270286.1 type II toxin-antitoxin system antitoxin HicB Antitoxin
JLZ97_RS11920 2510579..2510755 - 177 WP_001612987.1 type II toxin-antitoxin system mRNA interferase toxin HicA Toxin
JLZ97_RS11925 2510977..2511207 + 231 WP_000494244.1 YncJ family protein -
JLZ97_RS11930 2511299..2513260 - 1962 WP_001718255.1 23S rRNA 5-hydroxycytidine C2501 synthase -
JLZ97_RS11935 2513333..2513869 - 537 WP_000429147.1 DNA-binding transcriptional regulator SutR -
JLZ97_RS11940 2513922..2515136 + 1215 WP_072148478.1 BenE family transporter YdcO -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- flank IS/Tn - - 2515176..2516324 1148


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Cro/C1-type helix-turn-helix domain

(91-134)


Sequences

Toxin        


Download         Length: 59 a.a.        Molecular weight: 6725.78 Da        Isoelectric Point: 10.9223

>T290054 WP_001612987.1 NZ_LR882990:c2510755-2510579 [Escherichia coli]
VKQSEFRRWLESQGVDVANGSNHLKVRFHGMRSVMPRHPCDEIKEPLRKAIQKQLGLS

Download         Length: 177 bp

Antitoxin


Download         Length: 139 a.a.        Molecular weight: 15246.63 Da        Isoelectric Point: 4.7386

>AT290054 WP_001270286.1 NZ_LR882990:c2510533-2510117 [Escherichia coli]
MRYPVTLTPAPEGGYMVSFVDIPEALTQGETVAEAMEAAKDALLTAFDFYFEDNELIPLPSPLNSHDHFIEVPLSVASKV
LLLNAFLQSEITQQELARRIGKPKQEITRLFNLHHATKIDAVQLAAKALGKELSLVMV

Download         Length: 417 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3T4J978

Antitoxin

Source ID Structure

References