Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 2411472..2413060 Replicon chromosome
Accession NZ_LR882990
Organism Escherichia coli isolate L7_E1373_ETEC

Toxin (Protein)


Gene name hipA Uniprot ID A0A0K4CD26
Locus tag JLZ97_RS11505 Protein ID WP_001613069.1
Coordinates 2411738..2413060 (+) Length 441 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID -
Locus tag JLZ97_RS11500 Protein ID WP_001613070.1
Coordinates 2411472..2411738 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JLZ97_RS11500 2411472..2411738 + 267 WP_001613070.1 type II toxin-antitoxin system antitoxin HipB Antitoxin
JLZ97_RS11505 2411738..2413060 + 1323 WP_001613069.1 type II toxin-antitoxin system serine/threonine protein kinase toxin HipA Toxin
JLZ97_RS11510 2413331..2413599 + 269 Protein_2249 helix-turn-helix transcriptional regulator -
JLZ97_RS11515 2414032..2414595 + 564 WP_001296758.1 type 1 fimbrial major subunit FimA -
JLZ97_RS11520 2414956..2415666 + 711 WP_001195166.1 fimbria/pilus periplasmic chaperone -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(149-401)

Antitoxin

Cro/C1-type helix-turn-helix domain

(18-69)


Sequences

Toxin        


Download         Length: 441 a.a.        Molecular weight: 49334.97 Da        Isoelectric Point: 8.5823

>T290053 WP_001613069.1 NZ_LR882990:2411738-2413060 [Escherichia coli]
MPKLVTWMNNQRVGELTKLANGAHTFKYAPEWLASRYARPLSLSLPLQRGNITSDAVFNFFDNLLPDSPIVRDRIVKRYH
AKSRQPFDLLSEIGRDSVGAVTLIPEDETVTRPIMAWEKLTEARLEEVLTAYKADIPLGMIREENDFRISVAGAQEKTAL
LRIGNDWCIPKGITPTTHIIKLPIGEIRQPNATLDLSQSVDNEYYCLLLAKELGLNVPDAEIIKAGNVRALAVERFDRRW
NTERTVLLRLPQEDMCQTFGLPSSVKYESDGGPGIARIMAFLMGSSEALKDRYDFMKFQVFQWLIGATDGHAKNFSVFIQ
AGGSYRLTPFYDIISAFPVLGGAGIHISDLKLAMGLNASKGKKTAIDKIYPRHFLATAKVLRFPEVQMHEILSDFARMIP
AALDNVKTSLPTDFPENVVTAVETNVLRLHGRLSREYGIK

Download         Length: 1323 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10033.36 Da        Isoelectric Point: 4.9632

>AT290053 WP_001613070.1 NZ_LR882990:2411472-2411738 [Escherichia coli]
MMSFQKIYSPTQLANAMKLVRQQNGWTQSELAKKIGIKQATISNFENNPDNTSLTTFFKILQSLELSMTLCDTKNASPES
TEQQDLEW

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0K4CD26

Antitoxin

Source ID Structure

References