Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 912418..913072 Replicon chromosome
Accession NZ_LR882990
Organism Escherichia coli isolate L7_E1373_ETEC

Toxin (Protein)


Gene name cptA Uniprot ID S1PAM6
Locus tag JLZ97_RS04340 Protein ID WP_000244781.1
Coordinates 912665..913072 (+) Length 136 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID S1PPB1
Locus tag JLZ97_RS04335 Protein ID WP_000354046.1
Coordinates 912418..912684 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JLZ97_RS04315 908506..909939 - 1434 WP_032200731.1 6-phospho-beta-glucosidase BglA -
JLZ97_RS04320 909984..910295 + 312 WP_001182957.1 N(4)-acetylcytidine aminohydrolase -
JLZ97_RS04325 910459..911118 + 660 WP_000250274.1 hemolysin III family protein -
JLZ97_RS04330 911195..912175 - 981 WP_001613766.1 tRNA-modifying protein YgfZ -
JLZ97_RS04335 912418..912684 + 267 WP_000354046.1 FAD assembly factor SdhE Antitoxin
JLZ97_RS04340 912665..913072 + 408 WP_000244781.1 protein YgfX Toxin
JLZ97_RS04345 913112..913633 - 522 WP_001613762.1 flavodoxin FldB -
JLZ97_RS04350 913745..914641 + 897 WP_000806638.1 site-specific tyrosine recombinase XerD -
JLZ97_RS04355 914666..915376 + 711 WP_000715214.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
JLZ97_RS04360 915382..917115 + 1734 WP_000813202.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 136 a.a.        Molecular weight: 16061.99 Da        Isoelectric Point: 11.5202

>T290048 WP_000244781.1 NZ_LR882990:912665-913072 [Escherichia coli]
VVLWQSDLRVSWRAQWLSLLIHGLVAAVILLMPWPLSYTPLWMVLLSLVVFDCVRSQRRINARQGEIRLLMDGRLRWQGQ
EWSIVKAPWMIKSGMMLRLRSDSGKRQHLWLAADSMDEAEWRDLRRILLQQETQR

Download         Length: 408 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10547.12 Da        Isoelectric Point: 5.1599

>AT290048 WP_000354046.1 NZ_LR882990:912418-912684 [Escherichia coli]
MDINNKARIHWACRRGMRELDISIMPFFEHEYDSLSDDEKRIFIRLLECDDPDLFNWLMNHGKPADAELEMMVRLIQTRN
RERGPVAI

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB S1PAM6

Antitoxin

Source ID Structure
PDB 6B58
PDB 1X6I
PDB 1X6J
PDB 6C12
AlphaFold DB A0A7U9QD57

References