Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) ataRT/DUF1778(antitoxin)
Location 354597..355397 Replicon chromosome
Accession NZ_LR882990
Organism Escherichia coli isolate L7_E1373_ETEC

Toxin (Protein)


Gene name ataT Uniprot ID A0A0K4AFE4
Locus tag JLZ97_RS01560 Protein ID WP_001614005.1
Coordinates 354870..355397 (+) Length 176 a.a.

Antitoxin (Protein)


Gene name ataR Uniprot ID F4NNI1
Locus tag JLZ97_RS01555 Protein ID WP_001277108.1
Coordinates 354597..354863 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JLZ97_RS01535 350255..350923 + 669 WP_001718990.1 cell division ATP-binding protein FtsE -
JLZ97_RS01540 350916..351974 + 1059 WP_001042003.1 permease-like cell division protein FtsX -
JLZ97_RS01545 352219..353073 + 855 WP_000130217.1 RNA polymerase sigma factor RpoH -
JLZ97_RS01550 353344..354447 + 1104 WP_001021996.1 branched chain amino acid ABC transporter substrate-binding protein LivJ -
JLZ97_RS01555 354597..354863 + 267 WP_001277108.1 DUF1778 domain-containing protein Antitoxin
JLZ97_RS01560 354870..355397 + 528 WP_001614005.1 GNAT family N-acetyltransferase Toxin
JLZ97_RS01565 355394..355777 - 384 WP_001614003.1 aspartate 1-decarboxylase autocleavage activator PanM -
JLZ97_RS01570 356201..357310 + 1110 WP_001301528.1 high-affinity branched-chain amino acid ABC transporter substrate-binding protein LivK -
JLZ97_RS01575 357358..358284 + 927 WP_001295111.1 high-affinity branched-chain amino acid ABC transporter permease LivH -
JLZ97_RS01580 358281..359558 + 1278 WP_001614002.1 branched chain amino acid ABC transporter permease LivM -
JLZ97_RS01585 359555..360322 + 768 WP_000082101.1 high-affinity branched-chain amino acid ABC transporter ATP-binding protein LivG -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(88-150)

Antitoxin

Vibrio phage ICP1, Orf50

(8-86)


Sequences

Toxin        


Download         Length: 176 a.a.        Molecular weight: 19676.62 Da        Isoelectric Point: 7.3502

>T290047 WP_001614005.1 NZ_LR882990:354870-355397 [Escherichia coli]
MDDLTIEILTDDADYDLQRFDCGEEALNLFLTTHLVRQHRNKILRAYILCRNTPERQVLGYYTLSGSCFERAALPSKSKQ
KKIPYKNIPSVTLGRLAIDRSLQGQGWGATLVAHAMKVVWSASLAVGIHGLFVEALNEKAHTFYKSLGFIPLVGENENAL
FFPTKSIELLFTQSD

Download         Length: 528 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 9910.31 Da        Isoelectric Point: 10.0863

>AT290047 WP_001277108.1 NZ_LR882990:354597-354863 [Escherichia coli]
MSAVKKQRIDLRLTDDDKSMIEEAAAISNQSVSQFMLNSASQRAAEVIEQHRRVILNEESWTRVMDALSNPPSPGEKLKR
AAKRLQGM

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0K4AFE4

Antitoxin

Source ID Structure
PDB 6GTS
PDB 6AJN
PDB 6GTQ
PDB 6GTO
PDB 6GTR
PDB 6AJM
AlphaFold DB A0A829CN24

References