Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/-
Location 333259..333890 Replicon chromosome
Accession NZ_LR882990
Organism Escherichia coli isolate L7_E1373_ETEC

Toxin (Protein)


Gene name hicA Uniprot ID U9Y2A7
Locus tag JLZ97_RS01435 Protein ID WP_001259385.1
Coordinates 333259..333534 (+) Length 92 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID U9Y7E1
Locus tag JLZ97_RS01440 Protein ID WP_000593555.1
Coordinates 333531..333890 (+) Length 120 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JLZ97_RS01420 328263..329330 + 1068 WP_001614022.1 HlyD family efflux transporter periplasmic adaptor subunit -
JLZ97_RS01425 329327..332062 + 2736 WP_001614021.1 ribosome-associated ATPase/putative transporter RbbA -
JLZ97_RS01430 332062..333186 + 1125 WP_001314210.1 ABC transporter permease -
JLZ97_RS01435 333259..333534 + 276 WP_001259385.1 type II toxin-antitoxin system HicA family toxin Toxin
JLZ97_RS01440 333531..333890 + 360 WP_000593555.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
JLZ97_RS01445 334010..334411 - 402 WP_001190062.1 nickel-responsive transcriptional regulator NikR -
JLZ97_RS01450 334417..335223 - 807 WP_001614017.1 nickel import ATP-binding protein NikE -
JLZ97_RS01455 335220..335984 - 765 WP_001614016.1 nickel import ATP-binding protein NikD -
JLZ97_RS01460 335984..336817 - 834 WP_001008963.1 nickel ABC transporter permease subunit NikC -
JLZ97_RS01465 336814..337758 - 945 WP_000947068.1 nickel ABC transporter permease subunit NikB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 324385..333890 9505


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(30-80)

Antitoxin

Uncharacterised protein family HicB

(60-112)


Sequences

Toxin        


Download         Length: 92 a.a.        Molecular weight: 10199.94 Da        Isoelectric Point: 10.7076

>T290046 WP_001259385.1 NZ_LR882990:333259-333534 [Escherichia coli]
MRTKVQALRKKQKNTLDQIFKTPVPQGIKWSDIESLVKALGGEIKEGRGSRCKFILNMSVACFHRPHPSPDTDKGAVESV
RDWLLSIGVKP

Download         Length: 276 bp

Antitoxin


Download         Length: 120 a.a.        Molecular weight: 13402.27 Da        Isoelectric Point: 5.1987

>AT290046 WP_000593555.1 NZ_LR882990:333531-333890 [Escherichia coli]
MIKLKTPNSMEIAGQPAVITYVPELNAFRGKFLGLSGYCDFVSDSIQGLQKEGELSLREYLEDCKAAGIEPYARTEKIKT
FTLRYPESLSERLNNAAAQQQVSVNTYIIETLNERLNHL

Download         Length: 360 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A4P7TTW8

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9LKZ6

References