Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/RHH(antitoxin)
Location 1774..2204 Replicon plasmid 3
Accession NZ_LR882980
Organism Escherichia coli isolate L3_CS7_E2980

Toxin (Protein)


Gene name parE Uniprot ID -
Locus tag JLZ94_RS24835 Protein ID WP_001388374.1
Coordinates 2040..2204 (+) Length 55 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID A0A6Y0EDY2
Locus tag JLZ94_RS24830 Protein ID WP_000079939.1
Coordinates 1774..2043 (+) Length 90 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JLZ94_RS24825 1..858 + 858 WP_001388371.1 incFII family plasmid replication initiator RepA -
JLZ94_RS24830 1774..2043 + 270 WP_000079939.1 hypothetical protein Antitoxin
JLZ94_RS24835 2040..2204 + 165 WP_001388374.1 hypothetical protein Toxin
JLZ94_RS24840 2252..3175 + 924 WP_001415483.1 hypothetical protein -
JLZ94_RS24845 3617..3997 + 381 WP_001696636.1 HTH domain-containing protein -
JLZ94_RS24850 4109..4513 + 405 Protein_6 IS91 family transposase -
JLZ94_RS24855 4620..5456 - 837 WP_000480972.1 aminoglycoside O-phosphotransferase APH(6)-Id -
JLZ94_RS24860 5456..6259 - 804 WP_001082319.1 aminoglycoside O-phosphotransferase APH(3'')-Ib -
JLZ94_RS24865 6320..7135 - 816 WP_001043260.1 sulfonamide-resistant dihydropteroate synthase Sul2 -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Conjugative plasmid aph(6)-Id / aph(3'')-Ib / sul2 / blaTEM-1B - 1..72255 72255
- flank IS/Tn aph(6)-Id / aph(3'')-Ib / sul2 / blaTEM-1B - 4620..10493 5873


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 55 a.a.        Molecular weight: 6604.73 Da        Isoelectric Point: 7.1989

>T290043 WP_001388374.1 NZ_LR882980:2040-2204 [Escherichia coli]
MMEIFWTMLASQDRKRIREYIAEQNLIAAIELDERIGYFGRTHRLTPVLHLYYM

Download         Length: 165 bp

Antitoxin


Download         Length: 90 a.a.        Molecular weight: 10233.54 Da        Isoelectric Point: 6.7263

>AT290043 WP_000079939.1 NZ_LR882980:1774-2043 [Escherichia coli]
MAQVNMSLRIDAELKDAFMAAAKSMDRNGSQLIRDFMRQTVERQHNTWFRDQVEAGRQQLEHGDVLPHDMVESSAAAWRD
EMSRKVAGK

Download         Length: 270 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A6Y0EDY2

References