Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RHH(antitoxin)
Location 2209..2768 Replicon plasmid 2
Accession NZ_LR882979
Organism Escherichia coli isolate L3_CS7_E2980

Toxin (Protein)


Gene name relE Uniprot ID U9YB49
Locus tag JLZ94_RS24205 Protein ID WP_000421259.1
Coordinates 2493..2768 (+) Length 92 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID U9Y625
Locus tag JLZ94_RS24200 Protein ID WP_001178087.1
Coordinates 2209..2493 (+) Length 95 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JLZ94_RS24195 271..1302 + 1032 WP_003964539.1 replication initiation protein -
JLZ94_RS24200 2209..2493 + 285 WP_001178087.1 ribbon-helix-helix domain-containing protein Antitoxin
JLZ94_RS24205 2493..2768 + 276 WP_000421259.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
JLZ94_RS24210 3552..4688 + 1137 WP_000465104.1 hypothetical protein -
JLZ94_RS24215 4685..5890 + 1206 WP_000673444.1 TolC family protein -
JLZ94_RS24220 5847..6632 + 786 WP_000775193.1 hypothetical protein -
JLZ94_RS24225 6613..7239 + 627 WP_000620425.1 ATP-binding cassette domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Conjugative plasmid - csvA / eltB / eltA 1..112055 112055


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(3-90)

Antitoxin

Ribbon-helix-helix protein, CopG

(14-51)


Sequences

Toxin        


Download         Length: 92 a.a.        Molecular weight: 10736.45 Da        Isoelectric Point: 9.9324

>T290038 WP_000421259.1 NZ_LR882979:2493-2768 [Escherichia coli]
MELKWTSKALSDLARLYDFLVLASKPAAARTVQSLTQAPVILLTHPRMGEQLFQFEPREVRRIFAGEYEIRYELTGQTIY
VLRLWHTRENR

Download         Length: 276 bp

Antitoxin


Download         Length: 95 a.a.        Molecular weight: 10488.92 Da        Isoelectric Point: 5.6558

>AT290038 WP_001178087.1 NZ_LR882979:2209-2493 [Escherichia coli]
MQMKNNTAQATKVITAHVPLPMADKVDQMAARLERSRGWIIKQALSAWLAQEEERNRLTLEALDDVTSGQVIDHQAVQAW
ADSLSTDNPLPVPR

Download         Length: 285 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB U9YB49

Antitoxin

Source ID Structure
AlphaFold DB U9Y625

References