Detailed information of TA system TA290035

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): mosAT/AbiEii-AbiEi
• Location: 4345514..4347197
• Replicon: chromosome
• Accession: NZ_LR882978
• Organism: Escherichia coli isolate L3_CS7_E2980

Toxin (Protein)

• Gene name: mosT
• Uniprot ID: -
• Locus tag: JLZ94_RS21165
• Protein ID: WP_001385928.1
• Coordinates: 4346280..4347197 (+)
• Length: 306 a.a.

Antitoxin (Protein)

• Gene name: mosA
• Uniprot ID: -
• Locus tag: JLZ94_RS21160
• Protein ID: WP_200999689.1
• Coordinates: 4345514..4346287 (+)
• Length: 258 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
JLZ94_RS21145	4341382..4343466	+	2085	WP_001193075.1	protease Lon-related BREX system protein BrxL	-
JLZ94_RS21150	4343585..4344934	+	1350	WP_000766444.1	phospholipase	-
JLZ94_RS21155	4345110..4345430	-	321	Protein_4143	IS3 family transposase	-
JLZ94_RS21160	4345514..4346287	+	774	WP_200999689.1	type IV toxin-antitoxin system AbiEi family antitoxin	Antitoxin
JLZ94_RS21165	4346280..4347197	+	918	WP_001385928.1	nucleotidyl transferase AbiEii/AbiGii toxin family protein	Toxin
JLZ94_RS21170	4347491..4347658	+	168	WP_001356018.1	hypothetical protein	-
JLZ94_RS21175	4347711..4348373	-	663	WP_000357928.1	hypothetical protein	-
JLZ94_RS21180	4348377..4349087	-	711	WP_001219054.1	integrase arm-type DNA-binding domain-containing protein	-
JLZ94_RS21190	4349568..4350587	+	1020	WP_001349988.1	NADPH-dependent aldehyde reductase Ahr	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Nucleotidyl transferase AbiEii toxin, Type IV TA system (13-278)

Antitoxin

• Transcriptional regulator AbiEi antitoxin, N-terminal domain (1-93)

Sequences

Toxin

Protein

• Length: 306 a.a.
• Molecular weight: 34944.07 Da
• Isoelectric Point: 4.9206

>T290035 WP_001385928.1 NZ_LR882978:4346280-4347197 [Escherichia coli]
MDKTSPYYRQVALLVRALPWVANESCFALKGGTAINLFIHDFPRLSVDIDLAWIPLESREVALPNVREALTRIAAELKAQ
TGIRAVLQTHNPDEMRIIVTTDDAQIKIEVSPVARGTLYPPQERDIVGAVEEEFGFAALPVVSLPDLYGGKLCAALDRQH
PRDFYDVKMLLDTQGIDRSIFNGFIVYLLSHNRPLSEVLNPRWKDITEPFQNEFSGMTFEEVSLEELKEVPERMLSTLKT
HFTQQDFDFLMSFKRGEPDWNLAPEPHIQNLPAVQWKLRNIGQISEEKRAQSLEKLEKVMTEWLR

Nucleotide

• Length: 918 bp

Antitoxin

Protein

• Length: 258 a.a.
• Molecular weight: 29347.79 Da
• Isoelectric Point: 9.9889

>AT290035 WP_200999689.1 NZ_LR882978:4345514-4346287 [Escherichia coli]
MASKLNWLLQNTSPGSLVLQSWLTRNNISPSLAFKYAQNGWLIKLRAGVYARAGREPDWSDALWCLQNQLEAPVHLAGLS
SLSWQGRSHYLQLKQNQCWLSVENKAILPKWFKEFPAVEWLMVSALKLPDLDEKYRTELEVKGKRITASTPELAAYELLS
AIPQEISFEHAAELFQGLVNLNPRKVEKLLTLSQSVQTKRLYLFFASFYEHAWFKRIDTSKINLGSGNRQIVVNGKLNTQ
YQITVPENFTKKGISHG

Nucleotide

• Length: 774 bp